Evidence map›Paper›PMID 32872759›Full record

ArticleAsian spine journal2021

Diffusion Tensor Imaging of the Spinal Canal in Quantitative Assessment of Patients with Lumbar Spinal Canal Stenosis.

Masaki Norimoto, Yawara Eguchi, Hirohito Kanamoto, Yasuhiro Oikawa, Koji Matsumoto, Yoshitada Masuda, Takeo Furuya, Sumihisa Orita, Kazuhide Inage, Satoshi Maki and 10 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian spine journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Masaki NorimotoDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yawara EguchiDepartment of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido, Japan.
Hirohito KanamotoKanamoto Orthopaedic Clinic, Numazu, Japan.
Yasuhiro OikawaDepartment of Orthopaedic Surgery, Chiba Children's Hospital, Chiba, Japan.
Koji MatsumotoDepartment of Radiology, Chiba University Hospital, Chiba, Japan.
Yoshitada MasudaDepartment of Radiology, Chiba University Hospital, Chiba, Japan.
Takeo FuruyaDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Sumihisa OritaDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kazuhide InageDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Satoshi MakiDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yasuhiro ShigaDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hideyuki KinoshitaDepartment of Orthopaedic Surgery, Chiba Cancer Center, Chiba, Japan.
Koki AbeDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masahiro InoueDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tomotaka UmimuraDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Takashi SatoDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masashi SatoDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masahiro SuzukiDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Keigo EnomotoDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Seiji OhtoriDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Chiba University · JPChiba University Hospital · JPChiba Cancer Center · JPChiba Hospital · JPKumamoto Orthopedic Surgery Hospital · JPShizuoka City Shimizu Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designRetrospective observational study. PURPOSE: Lumbar spinal stenosis (LSS) has traditionally been evaluated morphologically, there is a paucity of literature on quantitative assessment of LSS. The purpose of this study was to investigate whether intraspinal diffusion tensor imaging (DTI) parameters such as apparent diffusion coefficient (ADC) and fractional anisotropy (FA) are useful for assessing LSS. OVERVIEW OF LITERATURE: Quantitative assessment of LSS is challenging.

methodsStudy participants comprised five healthy volunteers (mean age, 27.2 years) and 27 patients with LSS (mean age, 58.4 years) who were individually assessed using 3.0 Tesla magnetic resonance imaging. Intraspinal ADC and FA values of 10 intervertebral discs from healthy volunteers and 52 intervertebral discs from LSS patients were measured. Also, intraspinal canal area, Schizas classification (A: normal, B: mild stenosis, C: severe stenosis) and correlations with symptoms were investigated. Clinical symptoms were checked for the presence of low back pain (LBP), intermittent claudication (IMC), and bladder and bowel dysfunction (BBD).

resultsCompared to healthy individuals, LSS patients had significantly lower ADC (p<0.05) and significantly higher FA values (p<0.01). In Schizas classification, stenosis worsened from A to C. ADC values decreased significantly while FA values increased significantly in that order (p<0.05). A positive correlation was found between intraspinal canal area and ADC values (r=0.63, p<0.01) and a negative correlation between intraspinal canal area and FA values (p=-0.61, p<0.01). No correlations were noted between LBP and ADC or FA values. On the other hand, ADC values were significantly lower (p<0.05) and FA values were significantly higher (p<0.05) in patients with IMC or BBD.

conclusionsIntraspinal DTI parameters such as ADC and FA values were associated with the Schizas classification, intraspinal canal area, and clinical symptoms, suggesting that ADC and FA may be useful for quantitative assessment of LSS.

Indexed as

Apparent diffusion coefficientDiffusion tensor imagingFractional anisotropyLumbar spinal stenosis

Identifiers

PMID32872759
PMCPMC8055456
OpenAlexW3081723770

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.