ReviewThe Korean journal of internal medicine2020
Renal effects of uric acid: hyperuricemia and hypouricemia.
Review in The Korean journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05402397 (Losartan and Uric Acid Metabolism in Children With Proteinuric Nephropathies), which is not on this map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Losartan and Uric Acid Metabolism in Children With Proteinuric Nephropathies: a Cross-over Randomized Clinical Trail
Who cites it
66 citing papers in PubMed, 103 citations in OpenAlex.
- Effect of losartan on uric acid metabolism in children with proteinuric kidney disease: crossover randomized controlled clinical trial.Pediatric nephrology (Berlin, Germany) · 2025Trial
- Pharmacogenomic characterization of a uric acid metabolism-related signature associated with prognosis and drug sensitivity in gastric cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The mechanism of hypoxia-inducible factor-1α in gouty nephropathy.International urology and nephrology · 2026Review
- Low-level Blood Multiple Metals Exposure from Informal Jewelry Welding Alters Metabolomic and Lipidomic Profiles in Brazilian Women.Biological trace element research · 2026Article
- Uric Acid and Chronic Kidney Disease.Kidney medicine · 2026Review
- Post-transplant metabolic dysregulation: Insights and implications for kidney graft survival.World journal of nephrology · 2026Review
- Article
- Urinary lithogenic factors in urolithiasis patients with kidney disease and correlation with renal function.Frontiers in medicine · 2026Article
- First case report of hypouricemia associated with adjuvant imatinib therapy in a patient with small intestinal gastrointestinal stromal tumor.Frontiers in oncology · 2026Article
- Article
- Programmed cell death in gouty nephropathy: molecular mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Renal hypouricemia type 2 in a patient with latent autoimmune diabetes in adults: a case report and literature review.BMC nephrology · 2025Review
- Identification of the serum uric acid threshold with increasing risk for diabetic nephropathy in type 1 diabetes.Hormones (Athens, Greece) · 2025Article
- Nephropathogenic infectious bronchitis virus induces epithelial-mesenchymal transition of renal tubular epithelial cells through the TGF-β/p-P38 pathway causing uric acid excretion disorder in chickens.Journal of virology · 2025Article
- Integrative transcriptomic and metabolomic analysis explores mechanisms by which Astragalus membranaceus and Salvia miltiorrhiza ameliorates hypertensive renal damage.Scientific reports · 2025Article
- Clinical observations on arthroscopic removal of urate deposits in the knee: a seven-case series.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Outpatient crystalluria: prevalence, crystal types, and associations with comorbidities and urinary tract infections at a provincial hospital.Iranian journal of microbiology · 2025Article
- Dynamic changes in metabolic syndrome components and chronic kidney disease risk: a population-based prospective cohort study.BMC endocrine disorders · 2025Article
- Balancing Stone Prevention and Kidney Function: A Therapeutic Dilemma.Journal of clinical medicine · 2025Review
- High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes.Diabetology & metabolic syndrome · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although hyperuricemia has been associated with CKD in many studies, it remains controversial whether this is the cause or the result of decreased renal function. Recent observational studies of healthy populations and patients with CKD have reported that uric acid (UA) has an independent role in the development or progression of CKD. Experimental studies have shown several potential mechanisms by which hyperuricemia may cause or promote CKD. However, other reports have indicated an association between hypouricemia and CKD. This opposing effect is hypothesized to occur because UA is a major antioxidant in human plasma and is associated with oxidative stress. In this article, we discuss the potential association between UA imbalance and CKD and how they can be treated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.