ArticleBrain sciences2020
Conditioned Pain Modulation Effectiveness: An Experimental Study Comparing Test Paradigms and Analyzing Potential Predictors in a Healthy Population.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pain Modulation Effectiveness: An Experimental Study Using Repeated Conditioned Pain Modulation as an Intervention and Analyzing Potential Predictors in Healthy Adults.
Exploring Pain Modulation Mechanisms: A Study of TMS and Repeated Conditioned Pain Modulation
Who cites it
21 citing papers in PubMed.
- Impact of repeated exposure to CPM on CPM efficiency and pain sensitivity in healthy adults: a randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Trial
- Immersive visualization of movement in patients with hemophilic ankle arthropathy. Multicenter, single-blind, randomized clinical trial.Journal of rehabilitation medicine · 2024Trial
- Conditioned Pain Modulation and Pleasant Pain Relief as Complementary Processes Reflecting Individual Differences in Pain Coping: A Clustering Approach.European journal of pain (London, England) · 2026Article
- Sensory Blurring in Nociplastic Pain: The Role of Descending Inhibitory Dysfunction and Gut-Brain Axis Alterations in Older Adults.Geriatrics (Basel, Switzerland) · 2026Review
- Conditioned Pain Modulation Inter-Site Variability Study: Effect Sizes and Test-Retest Reliability of Two Models.European journal of pain (London, England) · 2026Article
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Exercise-Induced Hypoalgesia Following Blood Flow Restriction in Rotator Cuff Repair Rehabilitation: A Randomized Crossover Clinical Trial.Translational sports medicine · 2026Article
- Association between changes in conditioned pain modulation efficiency and pain sensitivity: a randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Investigation of Sensory and Neuropsychological Parameters in Migraine Sufferers: A Cross-Sectional Study with Negative Findings.Neurology and therapy · 2025Article
- Exploring the Spectrum of Temporal Summation and Conditioned Pain Modulation Responses in Pain-Free Individuals Using a Tonic Heat Pain and Cold Pressor Test Paradigms.European journal of pain (London, England) · 2025Observational
- Article
- Exploring the Impact of Affinity and Unpleasantness on Conditioned Pain Modulation among Healthy Individuals.Biomedicines · 2024Article
- Conditioned pain modulation (CPM) paradigm type affects its sensitivity as a biomarker of fibromyalgia.Scientific reports · 2024Article
- Body-site effect on CPM efficiency in healthy subjects: Central vs. peripheral stimulation.Heliyon · 2024Article
- Exercise-Induced Hypoalgesia in Patients with Chronic Whiplash-Associated Disorders: Differences between Subgroups Based on the Central Sensitization Inventory.Journal of clinical medicine · 2024Article
- Psychophysics of Pain: A Methodological Introduction.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- Factors Associated with Low Inter-Session Reliability of Conditioned Pain Modulation in Older People with or Without Chronic Musculoskeletal Pain.Journal of pain research · 2023Article
- The Contribution of Psychological Factors to Inter-Individual Variability in Conditioned Pain Modulation Is Limited in Young Healthy Subjects.Brain sciences · 2022Article
- Validation and Cross-Cultural Adaptation of the Spanish Version of the Pain Sensitivity Questionnaire (PSQ-S).Journal of clinical medicine · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conditioned pain modulation (CPM) is an endogenous pain inhibition phenomenon that can be summarized simply as one type of pain being able to inhibit another, which must be in a remote area in relation to the first pain. We aimed to compare the effectiveness of four CPM test paradigms as well as the association of the CPM effect with potential predictors in 72 healthy volunteers. Pressure pain from an algometer was used as the test stimulus, and pain provoked by cold water or ischemic pressure was used as the conditioning stimulus, applied either sequentially or in parallel. No significant differences were found between the test paradigms, although the cold-parallel test showed the most significant effect size (ηP
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.