ArticleJournal of clinical medicine2020
Deep Brain Stimulation Is Effective for Treatment-Resistant Depression: A Meta-Analysis and Meta-Regression.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cost-effectiveness and threshold analysis of deep brain stimulation vs. treatment-as-usual for treatment-resistant depression.Translational psychiatry · 2024Pooled it
- Effects of deep brain stimulation on cognitive functioning in treatment-resistant depression: a systematic review and meta-analysis.Molecular psychiatry · 2023Pooled it
- Implantable Neuromodulation Devices in Psychiatry: Human Fidelity and Implementation Challenges.The American journal of psychiatry · 2026Article
- Comparing apples and oranges in TRD treatment: the importance of assumptions in network meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Reply to mol: Comparing apples and oranges in TRD treatment: the importance of assumptions in network meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Deep Brain Stimulation in Treatment-Resistant Psychiatric Disorders: Efficacy, Safety, and Future Directions.Brain sciences · 2025Review
- Fiber Distribution and Myelination of Dopaminergic Neurons in the Medial Forebrain Bundle of a Rodent Depression Model.Journal of neuroscience research · 2025Article
- Treatment-resistant depression with poor response to deep brain stimulation improves with psychotherapy: case series.Annals of general psychiatry · 2025Article
- Deep brain stimulation improves symptoms across all dimensions in treatment-resistant depression.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Epitranscriptomic Analysis of the Ventral Hippocampus in a Mouse Model of Post-Traumatic Stress Disorder Following Deep Brain Stimulation Treatment of the Basolateral Amygdala.Brain sciences · 2025Article
- Target engagement of the subgenual anterior cingulate cortex with transcranial temporal interference stimulation in major depressive disorder: a protocol for a randomized sham-controlled trial.Frontiers in neuroscience · 2024Article
- Happy Birthday "One Flew Over the Cuckoo's Nest": A Momentous Tale in the Quest for an Effective and Ethical Approach to Psychosurgery.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Article
- Major depressive disorder.Nature reviews. Disease primers · 2023Review
- Safety and precision of frontal trajectory of lateral habenula deep brain stimulation surgery in treatment-resistant depression.Frontiers in neurology · 2023Article
- Molecular basis and clinical perspectives of deep brain stimulation for major depressive disorder.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Biomarkers for Deep Brain Stimulation in Animal Models of Depression.Neuromodulation : journal of the International Neuromodulation Society · 2022Review
- Various neuromodulation methods including Deep Brain Stimulation of the medial forebrain bundle combined with psychopharmacotherapy of treatment-resistant depression-Case report.Frontiers in psychiatry · 2022Article
- Special Issue: Trends in Clinical Deep Brain Stimulation.Journal of clinical medicine · 2021Article
- Risk Assessment of Electroconvulsive Therapy in Clinical Routine: A 3-Year Analysis of Life-Threatening Events in More Than 3,000 Treatment Sessions.Frontiers in psychology · 2021Article
- Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is a leading cause of disability and a significant cause of mortality worldwide. Approximately 30-40% of patients fail to achieve clinical remission with available pharmacological treatments, a clinical course termed treatment-resistant depression (TRD). Numerous studies have investigated deep brain stimulation (DBS) as a therapy for TRD. We performed a meta-analysis to determine efficacy and a meta-regression to compare stimulation targets. We identified and screened 1397 studies. We included 125 citations in the qualitative review and considered 26 for quantitative analysis. Only blinded studies that compared active DBS to sham stimulation (k = 12) were included in the meta-analysis. The random-effects model supported the efficacy of DBS for TRD (standardized mean difference = -0.75, <0 favors active stimulation;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.