ArticleMaterials (Basel, Switzerland)2020
Biodegradable and Drug-Eluting Inorganic Composites Based on Mesoporous Zinc Oxide for Urinary Stent Applications.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Present and future of ureteral stent technology: a review by the EAU endourology section.World journal of urology · 2026Review
- Engineering Mesoporous Silica Hosts for Ultrasmall ZnO Nanoparticles: A Dendritic Polymer-Assisted Strategy Towards Sustainable, Safe, and Effective Antibacterial Systems.Nanomaterials (Basel, Switzerland) · 2025Article
- Investigation of the Combined Impact of Zinc Oxide Nanoparticles and Bacterial Cellulose Nanocrystals on the Bond Strength to Dentin and Fracture Resistance of Resin-Modified Glass Ionomer Cement in Primary Molars.Clinical and experimental dental research · 2025Article
- Advancements in biodegradable implants: evaluation in large animal surgical models.Annals of medicine and surgery (2012) · 2025Review
- Impact of Mesoporous Zinc Oxide Nanoparticles on Diametral Tensile Strength and Flexural Strength of Resin-Modified Glass Ionomer Cement: An In-Vitro Study.Frontiers in dentistry · 2025Article
- Assessment of the Antimicrobial Properties of Mesoporous Zinc Oxide Nanoparticles AgainstInternational journal of dentistry · 2025Article
- Effect of Mesoporous Zinc Oxide Nanoparticle Incorporation on the Bond Strength of Resin-Modified Glass Ionomer Cement to Enamel and Dentin: An In Vitro Study.International journal of dentistry · 2025Article
- Examining the Impact of Mesoporous Zinc Oxide Nanoparticle Inclusion on the Surface Microhardness and Roughness of Resin-Modified Glass Ionomer Cement: An In Vitro Analysis.International journal of dentistry · 2025Article
- Evaluating mesoporous zinc oxide nanoparticles for dentin pretreatment: Synthesis, characterization, and bond strength performance with a universal adhesive.Dental research journal · 2025Article
- Ultrasound-assisted water oxidation: unveiling the role of piezoelectric metal-oxide sonocatalysts for cancer treatment.Biomedical microdevices · 2024Article
- Synthesis and characterization of mesoporous zinc oxide nanoparticles and evaluation of their biocompatibility in L929 fibroblasts.Clinical and experimental dental research · 2024Article
- Recent development and future application of biodegradable ureteral stents.Frontiers in bioengineering and biotechnology · 2024Review
- Mesoporous Materials Make Hydrogels More Powerful in Biomedicine.Gels (Basel, Switzerland) · 2023Review
- Special Issue "Metal and Metal Oxide Nanoparticles: Design, Characterization, and Biomedical Applications".Materials (Basel, Switzerland) · 2021Article
- Improved Bacteriostatic and Anticorrosion Effects of Polycaprolactone/Chitosan Coated Magnesium via Incorporation of Zinc Oxide.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Conventional technologies for ureteral stent fabrication suffer from major inconveniences such as the development of encrustations and bacteria biofilm formation. These drawbacks typically lead to the failure of the device, significant patient discomfort and an additional surgery to remove and replace the stent in the worst cases. This work focuses on the preparation of a new nanocomposite material able to show drug elution properties, biodegradation and eventually potential antibacterial activity. Poly(2-hydroxyethyl methacrylate) or the crosslinked poly(2-hydroxyethyl methacrylate)-co-poly(acrylic acid) hydrogels were prepared by the radical polymerization method and combined with a biodegradable and antibacterial filling agent, i.e., flower-like Zinc Oxide (ZnO) micropowders obtained via the hydrothermal route. The physico-chemical analyses revealed the correct incorporation of ZnO within the hydrogel matrix and its highly mesoporous structure and surface area, ideal for drug incorporation. Two different anti-inflammatory drugs (Ibuprofen and Diclofenac) were loaded within each composite and the release profile was monitored up to two weeks in artificial urine (AU) and even at different pH values in AU to simulate pathological conditions. The addition of mesoporous ZnO micropowders to the hydrogel did not negatively affect the drug loading properties of the hydrogel and it was successfully allowed to mitigate undesirable burst-release effects. Furthermore, the sustained release of the drugs over time was observed at neutral pH, with kinetic constants (k) as low as 0.05 h
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.