ArticleInternational journal of molecular sciences2020
Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial.Frontiers in endocrinology · 2024Trial
- Personalized Combination of a Ketogenic Diet and Low-Dose Semaglutide for Cardiometabolic Health: A Retrospective Case Series.Journal of personalized medicine · 2026Article
- Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- β-Hydroxybutyrate Reduces Body Weight by Modulating Fatty Acid Oxidation and Beiging in the Subcutaneous Adipose Tissue of DIO Mice.International journal of molecular sciences · 2025Article
- Insulin resistance reduction, intermittent fasting, and human growth hormone: secondary analysis of a randomized trial.npj metabolic health and disease · 2024Article
- The Role of Adipocytes Recruited as Part of Tumor Microenvironment in Promoting Colorectal Cancer Metastases.International journal of molecular sciences · 2024Review
- Periodic Fasting and Acute Cardiac Events in Patients Evaluated for COVID-19: An Observational Prospective Cohort Study.Nutrients · 2024Observational
- Article
- Ketones with a twist: Tipping the heart's hat to fat.Obesity (Silver Spring, Md.) · 2024Article
- Intermittent fasting and changes in clinical risk scores: Secondary analysis of a randomized controlled trial.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- Yerba Maté (Nutrients · 2023Article
- Review
- Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-BasedAntioxidants (Basel, Switzerland) · 2022Article
- The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity?Nutrients · 2022Review
- Role of nutritional ketosis in the improvement of metabolic parameters following bariatric surgery.World journal of diabetes · 2022Article
- Article
- Randomized controlled trial of once-per-week intermittent fasting for health improvement: the WONDERFUL trial.European heart journal open · 2021Article
- The Metabolic Effects of Ketones.International journal of molecular sciences · 2021Article
- Mitochondrial Lipid Signaling and Adaptive Thermogenesis.Metabolites · 2021Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe rampant growth of obesity worldwide has stimulated explosive research into human metabolism. Energy expenditure has been shown to be altered by diets differing in macronutrient composition, with low-carbohydrate, ketogenic diets eliciting a significant increase over other interventions. The central aim of this study was to explore the effects of the ketone β-hydroxybutyrate (βHB) on mitochondrial bioenergetics in adipose tissue.
methodsWe employed three distinct systems-namely, cell, rodent, and human models. Following exposure to elevated βHB, we obtained adipose tissue to quantify mitochondrial function.
resultsIn every model, βHB robustly increased mitochondrial respiration, including an increase of roughly 91% in cultured adipocytes, 113% in rodent subcutaneous adipose tissue (SAT), and 128% in human SAT. However, this occurred without a commensurate increase in adipose ATP production. Furthermore, in cultured adipocytes and rodent adipose, we quantified and observed an increase in the gene expression involved in mitochondrial biogenesis and uncoupling status following βHB exposure.
conclusionsIn conclusion, βHB increases mitochondrial respiration, but not ATP production, in mammalian adipocytes, indicating altered mitochondrial coupling. These findings may partly explain the increased metabolic rate evident in states of elevated ketones, and may facilitate the development of novel anti-obesity interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.