Evidence map›Paper›PMID 32872240›Full record

ArticleInternational journal of molecular sciences2020

Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice.

Huaikai Shi, Tsun-Ho Lo, Duncan Ma, Brenton Condor, Brian Lesmana, Roxanne J Parungao, Kevin H-Y Tsai, Sarah Kim, Hsiao-Ting Chen, Pablo A Silveira and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Determination of Burn Size in Mouse Models of Burn Injury: A Scoping Review of Studies Leveraging Scald and Contact Burns.Journal of burn care & research : official publication of the American Burn Association · 2025
    Pooled it
  2. Article
  3. Hormonal interventions in skin wounds - a mini review.Molecular medicine (Cambridge, Mass.) · 2024
    Review
  4. Review
  5. Article
  6. Healing Mechanisms in Cutaneous Wounds: Tipping the Balance.Tissue engineering. Part B, Reviews · 2022
    Review
  7. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone electrospun scaffolds accelerate burn wound healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Huaikai ShiBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.ORCID 0000-0002-8269-2981
Tsun-Ho LoDendritic Cell Research, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.ORCID 0000-0003-0229-6004
Duncan MaBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Brenton CondorBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Brian LesmanaBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Roxanne J ParungaoBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Kevin H-Y TsaiAdrenal Steroids Laboratory, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Sarah KimBone Biology Group, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Hsiao-Ting ChenDendritic Cell Research, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Pablo A SilveiraDendritic Cell Research, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Zhe LiBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Mark S CooperAdrenal Steroids Laboratory, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.ORCID 0000-0003-3112-7728
Ulla SimanainenAndrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
David J HandelsmanAndrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.ORCID 0000-0002-4200-7476
Peter K MaitzBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
Yiwei WangBurns Research and Reconstructive Surgery, ANZAC Research Institute, University of Sydney, Sydney 2139, Australia.
The University of Sydney · AU

Funding

Australia National Health and Medical Research Council APP1100296
6 · The paper itself

Abstract

Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic approach in treating major burn injury. In the present study, mice received systemic androgen treatment post major burn injury. Wound healing rate and body weight were monitored over 21 days. The serum level of inflammatory cytokines/chemokines were measured using multiplex immunoassays. In addition, splenocyte enumeration was performed by flow cytometry. Healing phases of inflammation, re-epithelialization, cell proliferation and collagen deposition were also examined. In results, DHT treated mice lost less weight and displayed accelerated wound healing but has no impact on hypermetabolism. Mice, after burn injury, displayed acute systemic inflammatory responses over 21 days. DHT treatment shortened the systemic inflammatory response with reduced splenic weight and monocyte numbers on day 14 and 21. DHT treatment also reduced wound infiltrating macrophage numbers. In conclusion, DHT treatment facilitates local wound healing by accelerating the resolution of inflammation, but not through alterations of post-burn hypermetabolic response.

Indexed as

AndrogensAnimalsBody WeightBurnsCell ProliferationCollagenCytokinesDihydrotestosteroneDisease Models, AnimalMaleMiceSpleenWound HealingAndrogensCollagenCytokinesDihydrotestosteroneandrogensdihydrotestosteroneinflammationmajor burn injurymouse modelwound healing

Identifiers

PMID32872240
PMCPMC7504698
OpenAlexW3082957029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.