Evidence map›Paper›PMID 32872220›Full record

ArticleJournal of clinical medicine2020

Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development.

Melanie Langheinrich, Stefan Wirtz, Barbara Kneis, Matthias M Gittler, Olaf Tyc, Robert Schierwagen, Maximilian Brunner, Christian Krautz, Georg F Weber, Christian Pilarsky and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Oncoimmunology · 2026
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  10. Intratumoral microorganisms in tumors of the digestive system.Cell communication and signaling : CCS · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Liquid biopsies and cancer omics.Cell death discovery · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Melanie LangheinrichDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.
Stefan WirtzDepartment of Internal Medicine 1, University Hospital of Erlangen, 91054 Erlangen, Germany.
Barbara KneisDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.
Matthias M GittlerDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.
Olaf TycTranslational Hepatology, Department of Internal Medicine I, University Clinic Frankfurt, 60590 Frankfurt, Germany.ORCID 0000-0001-9949-0975
Robert SchierwagenTranslational Hepatology, Department of Internal Medicine I, University Clinic Frankfurt, 60590 Frankfurt, Germany.ORCID 0000-0002-2195-3666
Maximilian BrunnerDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.
Christian KrautzDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.
Georg F WeberDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.ORCID 0000-0003-1175-4505
Christian PilarskyDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.ORCID 0000-0002-7968-3283
Jonel TrebickaTranslational Hepatology, Department of Internal Medicine I, University Clinic Frankfurt, 60590 Frankfurt, Germany.ORCID 0000-0002-7028-3881
Abbas AgaimyDepartment of Pathology, University Hospital of Erlangen, 91054 Erlangen, Germany.
Robert GrützmannDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.
Stephan KerstingDepartment of Surgery, University Hospital of Erlangen, 91054 Erlangen, Germany.
Universitätsklinikum Erlangen · DEGoethe University Frankfurt · DE

Funding

Tumorzentrum Erlangen 2019
6 · The paper itself

Abstract

Postoperative complications after pancreatic surgery are still a significant problem in clinical practice. The aim of this study was to characterize and compare the microbiomes of different body compartments (bile duct, duodenal mucosa, pancreatic tumor lesion, postoperative drainage fluid, and stool samples; preoperative and postoperative) in patients undergoing pancreatic surgery for suspected pancreatic cancer, and their association with relevant clinical factors (stent placement, pancreatic fistula, and gland texture). For this, solid (duodenal mucosa, pancreatic tumor tissue, stool) and liquid (bile, drainage fluid) biopsy samples of 10 patients were analyzed using 16s rRNA gene next-generation sequencing. Our analysis revealed: (i) a distinct microbiome in the different compartments, (ii) markedly higher abundance of

Indexed as

16S rRNA sequencingmicrobiomepancreatic cancerpancreatic surgerypostoperative complications

Identifiers

PMID32872220
PMCPMC7563524
OpenAlexW3082018833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.