ArticlePolymers2020
Topography-Mediated Myotube and Endothelial Alignment, Differentiation, and Extracellular Matrix Organization for Skeletal Muscle Engineering.
Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Functionalized Multi-Walled Carbon Nanotube Enhanced Myogenic Differentiation for Aligned Topography-Induced Skeletal Muscle Engineering.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Modulation of Biomaterial-Associated Fibrosis by Means of Combined Physicochemical Material Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Developing Porous Fibrin Scaffolds with Tunable Anisotropic Features to Direct Myoblast Orientation.Tissue engineering. Part C, Methods · 2024Article
- 3D bioprinting using a new photo-crosslinking method for muscle tissue restoration.NPJ Regenerative medicine · 2023Article
- Optimization of Parylene C and Parylene N thin films for use in cellular co-culture and tissue barrier models.Scientific reports · 2023Article
- Porous biomaterial scaffolds for skeletal muscle tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- A Beginner's Guide to the Characterization of Hydrogel Microarchitecture for Cellular Applications.Gels (Basel, Switzerland) · 2022Review
- Topography-Mediated Enhancement of Nonviral Gene Delivery in Stem Cells.Pharmaceutics · 2022Article
- The Development of Biomimetic Aligned Skeletal Muscles in a Fully 3D Printed Microfluidic Device.Biomimetics (Basel, Switzerland) · 2021Article
- Regulation of Myogenic Differentiation by Topologically Microgrooved Surfaces for Skeletal Muscle Tissue Engineering.ACS omega · 2021Article
- Advances in Biofabrication for Tissue Engineering and Regenerative Medicine Applications.Polymers · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Understanding the response of endothelial cells to aligned myotubes is important to create an appropriate environment for tissue-engineered vascularized skeletal muscle. Part of the native tissue environment is the extracellular matrix (ECM). The ECM is a supportive scaffold for cells and allows cellular processes such as proliferation, differentiation, and migration. Interstitial matrix and basal membrane both comprise proteinaceous and polysaccharide components for strength, architecture, and volume retention. Virtually all cells are anchored to their basal lamina. One of the physical factors that affects cell behavior is topography, which plays an important role on cell alignment. We tested the hypothesis that topography-driven aligned human myotubes promote and support vascular network formation as a prelude to in vitro engineered vascularized skeletal muscle. Therefore, we used a PDMS-based topography substrate to investigate the influence of pre-aligned myotubes on the network formation of microvascular endothelial cells. The aligned myotubes produced a network of collagen fibers and laminin. This network supported early stages of endothelial network formation.
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Registered trials
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