Evidence map›Paper›PMID 32872192›Full record

ArticleInternational journal of molecular sciences2020

The Impact of Ang-(1-9) and Ang-(3-7) on the Biological Properties of Prostate Cancer Cells by Modulation of Inflammatory and Steroidogenesis Pathway Genes.

Kamila Domińska, Karolina Kowalska, Kinga Anna Urbanek, Dominika Ewa Habrowska-Górczyńska, Tomasz Ochędalski, Agnieszka Wanda Piastowska Ciesielska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kamila DomińskaDepartment of Comparative Endocrinology, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.ORCID 0000-0001-7501-8369
Karolina KowalskaDepartment of Cell Cultures and Genomic Analysis, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.ORCID 0000-0001-6067-4064
Kinga Anna UrbanekDepartment of Cell Cultures and Genomic Analysis, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.ORCID 0000-0002-5476-8432
Dominika Ewa Habrowska-GórczyńskaDepartment of Cell Cultures and Genomic Analysis, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.ORCID 0000-0002-0699-7441
Tomasz OchędalskiDepartment of Comparative Endocrinology, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.
Agnieszka Wanda Piastowska CiesielskaDepartment of Cell Cultures and Genomic Analysis, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.ORCID 0000-0001-7462-8528
Medical University of Lodz · PL

Funding

Medical University of Lodz 502-03/0-078-04/502-04-030Medical University of Lodz 503/0-078-04/503-01-001
6 · The paper itself

Abstract

The local renin-angiotensin system (RAS) plays an important role in the pathophysiology of the prostate, including cancer development and progression. The Ang-(1-9) and Ang-(3-7) are the less known active peptides of RAS. This study examines the influence of these two peptide hormones on the metabolic activity, proliferation and migration of prostate cancer cells. Significant changes in MTT dye reduction were observed depending on the type of angiotensin and its concentration as well as time of incubation. Ang-(1-9) did not regulate the 2D cell division of either prostate cancer lines however, it reduced the size of LNCaP colonies formed in soft agar, maybe through down-regulation of the

Indexed as

Angiotensin IAngiotensin IICell DivisionCell Line, TumorCell MovementCell ProliferationCell SizeCholesterolEstrogen Receptor alphaEstrogen Receptor betaGene Expression Regulation, NeoplasticHumansMalePC-3 CellsPeptide FragmentsProstatic NeoplasmsAngiotensin Iangiotensin I (1-9)Angiotensin IIangiotensin II (3-7)AR protein, humanCholesterolESR1 protein, humanESR2 protein, humanEstrogen Receptor alphaEstrogen Receptor betaPeptide FragmentsReceptors, AndrogenTestosteroneangiotensinmigrationNF-kBproliferationprostate cancerRASsteroidogenesis

Identifiers

PMID32872192
PMCPMC7504072
OpenAlexW3082420080

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.