Evidence map›Paper›PMID 32872159›Full record

ReviewInternational journal of molecular sciences2020

Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective.

Barbora Smolková, Adam Frtús, Mariia Uzhytchak, Mariia Lunova, Šárka Kubinová, Alexandr Dejneka, Oleg Lunov

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05924867 (Application of Plasma Activated Saline in Wound Treatment), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05924867 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Application of Plasma Activated Saline in Wound Treatment

TypeinterventionalSponsorFirst Affiliated Hospital Xi'an Jiaotong UniversityRan2023 to 2024Enrolled162ConditionsWound, Wound Infection, Wound HealArmsplasma activated saline, Routine nursing
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barbora SmolkováDepartment of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Adam FrtúsDepartment of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Mariia UzhytchakDepartment of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Mariia LunovaDepartment of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.ORCID 0000-0002-5795-7781
Šárka KubinováDepartment of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.ORCID 0000-0003-1674-4779
Alexandr DejnekaDepartment of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.ORCID 0000-0002-5116-8781
Oleg LunovDepartment of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.ORCID 0000-0003-2922-8896

Funding

Czech Ministry of Education, Youth and Sports SOLID21 - CZ.02.1.01/0.0/0.0/16_019/0000760
6 · The paper itself

Abstract

The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication. In recent years, the NTP field considerably progresses in the modulation of immune cell function leading to promising in vivo results. In fact, understanding the underlying cellular mechanisms triggered by NTP remains incomplete. In order to boost the field closer to real-life clinical applications, there is a need for a critical overview of the current state-of-the-art. In this review, we conduct a critical analysis of the NTP-triggered modulation of immune cells. Importantly, we analyze pitfalls in the field and identify persisting challenges. We show that the identification of misconceptions opens a door to the development of a research strategy to overcome these limitations. Finally, we propose the idea that solving problems highlighted in this review will accelerate the clinical translation of NTP-based treatments.

Indexed as

Gene Expression RegulationHumansImmunity, CellularPlasma GasesSignal TransductionPlasma Gasescell signalingcytotoxicityimmunomodulationnon-thermal plasma

Identifiers

PMID32872159
PMCPMC7503900

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.