Evidence map›Paper›PMID 32871779›Full record

ArticleIn vivo (Athens, Greece)

Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart.

Savas Ustunova, Selcuk Takir, Nadim Yilmazer, Huri Bulut, Didem Altindirek, Ozden Hatirnaz Ng, Cihan Demirci Tansel, B Sonmez Uydes Dogan, Ugur Ozbek, Elif Ilkay Armutak and 1 more

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Black gas, bright future: HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Savas UstunovaDepartment of Physiology, School of Medicine, Bezmialem Vakif University, Istanbul, Turkey sustunova@bezmialem.edu.tr.
Selcuk TakirDepartment of Medical Pharmacology, School of Medicine, Giresun University, Giresun, Turkey.
Nadim YilmazerDepartment of Biology, Faculty of Arts and Sciences, Namik Kemal University, Tekirdag, Turkey.
Huri BulutDepartment of Medical Biochemistry, School of Medicine, Istinye University, Istanbul, Turkey.
Didem AltindirekDepartment of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Ozden Hatirnaz NgDepartment of Medical Biology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Cihan Demirci TanselDepartment of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.
B Sonmez Uydes DoganDepartment of Pharmacology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
Ugur OzbekDepartment of Medical Genetics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Elif Ilkay ArmutakDepartment of Histology and Embryology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Ebru Gurel GurevinDepartment of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.
Istanbul University · TRAcıbadem Adana Hospital · TRBezmiâlem Vakıf Üniversitesi · TRGiresun University · TRIstinye University · TRNamık Kemal University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study was designed to provide further evidence for the interactions between hydrogen sulfide (H MATERIALS AND

methodsRat hearts were studied with the Langendorff technique using the H

resultsNaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME.

conclusionH

Indexed as

Hydrogen SulfideReperfusion InjuryAnimalsCystathionine gamma-LyaseIschemiaNitric OxideRatsCystathionine gamma-LyaseHydrogen SulfideNitric OxideHydrogen sulfideischemia/reperfusion injuryisolated heartnitric oxideoxidative damage

Identifiers

PMID32871779
PMCPMC7652485
OpenAlexW3082698262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.