Evidence map›Paper›PMID 32871758›Full record

ArticleIn vivo (Athens, Greece)

Effect of 7,12-Dimethylbenz(α)anthracene on the Expression of miR-330, miR-29a, miR-9-1, miR-9-3 and the mTORC1 Gene in CBA/Ca Mice.

Andras Tomesz, Laszlo Szabo, Richard Molnar, Arpad Deutsch, Richard Darago, Domokos Mathe, Ferenc Budan, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andras TomeszDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary tomesza@gmail.com.
Laszlo SzaboDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Richard MolnarDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Arpad DeutschDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Richard DaragoDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Domokos MatheDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Ferenc BudanDepartment of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
Nowrasteh GhodratollahDepartment of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
Timea VarjasDepartment of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
Balazs NemethDepartment of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
Istvan KissDepartment of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
University of Pecs · HUSemmelweis University · HUUniversity of Pannonia · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimDevelopment of malignant tumors is preceded by molecular biological events. Our aim was to establish an assay panel by using miRNAs and other genes for the rapid screening of potential carcinogens or chemopreventive agents. MATERIALS AND

methodsSix male and 6 female CBA/Ca mice received 20 mg/bwkg 7,12-dimethylbenz(α)anthracene (DMBA) intraperitoneally, and 24 h later RNA was isolated from parenchymal organs. Expression of miR-330, miR-29a, miR-9-1, miR-9-3 and mTORC1 was analysed by real time polymerase chain reaction and compared to non-treated controls.

resultsDMBA caused significant alterations in the expression of the studied genes. The most profound changes were the strongly elevated miR-9-3 and mTORC1 expressions in female mice in all organs studied.

conclusionmiR-9-3 and mTORC1 expression in female mice were found to be the most suitable biomarkers for rapid identification of possible carcinogenic effects.

Indexed as

9,10-Dimethyl-1,2-benzanthraceneMicroRNAsAnimalsAnthracenesCarcinogensFemaleMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred CBA9,10-Dimethyl-1,2-benzanthraceneAnthracenesCarcinogensMechanistic Target of Rapamycin Complex 1MicroRNAsMIRN9 microRNA, mouse7,12-dimethylbenz(α)anthracenecarcinogenicityDMBAGene expressionmicroRNAmiR-29amiR-330miR-9-1miR-9-3mTORC1

Identifiers

PMID32871758
PMCPMC7652467
OpenAlexW3082897652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.