ArticleAnnals of pediatric endocrinology & metabolism2020
Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review.
Article in Annals of pediatric endocrinology & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Meta-analysis of machine learning models for the diagnosis of central precocious puberty based on clinical, hormonal (laboratory) and imaging data.Frontiers in endocrinology · 2024Pooled it
- Hypogonadotropic Hypogonadism in a Central Obesity Patient with 46, XY, t(1; 10)(q42; q24).JBRA assisted reproduction · 2025Article
- Association of Serum Vascular Endothelial Growth Factor-A With Pubertal Stage by Sex and Its Relationship With Precocious Puberty in Girls.Journal of Korean medical science · 2025Article
- Investigating the Characteristics of Pelvic Ultrasound in Girls With Their First Menstrual Cycle: A Two-Center Cross-Sectional Study.Health science reports · 2025Article
- Interpretable XGBoost model identifies idiopathic central precocious puberty in girls using four clinical and imaging features.BMC endocrine disorders · 2025Article
- Hyaluronidase 2 deficiency due to novel compound heterozygous variants in HYAL2: a case report of siblings with HYAL2 deficiency showing different clinical severity and literature review.Journal of human genetics · 2025Review
- The effect of obesity on the GnRH stimulation test in girls with idiopathic central precocious puberty.European journal of pediatrics · 2025Article
- Impact of BMI on basal LH in premenarcheal girls with idiopathic central precocious puberty.Frontiers in endocrinology · 2025Article
- Predictive value of transabdominal pelvic ultrasonography for the diagnosis of central precocious puberty: A single-center observational retrospective study.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2024Article
- Assessment of Quality of Life and Behavioral Problems in Children with Central Precocious Puberty.Oman medical journal · 2024Article
- Urinary gonadotropin assay on 24-h collections as a tool to detect early central puberty onset in girls: determination of predictive thresholds.Human reproduction (Oxford, England) · 2024Article
- A Short-Duration Gonadotropin-Releasing Hormone Stimulation Test for the Diagnosis of Central Precocious Puberty.Medicina (Kaunas, Lithuania) · 2023Article
- Comparison of the effect of gonadotropin-releasing hormone agonist dosage in girls with central precocious puberty.Annals of pediatric endocrinology & metabolism · 2023Article
- Comparison of Makorin Ring Finger Protein 3 Levels Between Obese and Normal Weight Patients with Central Precocious PubertyJournal of clinical research in pediatric endocrinology · 2023Article
- Machine Learning Approach for Prediction of the Test Results of Gonadotropin-Releasing Hormone Stimulation: Model Building and Implementation.Diagnostics (Basel, Switzerland) · 2023Article
- Differential diagnosis of precocious puberty in girls during the COVID-19 pandemic: a pilot study.BMC pediatrics · 2023Article
- Precocious and accelerated puberty in children with neurofibromatosis type 1: results from a close follow-up of a cohort of 45 patients.Hormones (Athens, Greece) · 2023Article
- Central precocious puberty in Sudan: 10 years' experience of paediatric endocrinology centres.Sudanese journal of paediatrics · 2023Article
- Face-sparing Congenital Generalized Lipodystrophy Type 1 Associated With Nonclassical Congenital Adrenal Hyperplasia.The Journal of clinical endocrinology and metabolism · 2022Article
- Association of Early Pubertal Onset in Female Rats With Inhalation of Lavender Oil.Journal of Korean medical science · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gonadotropin-releasing hormone (GnRH) stimulation test is a valuable tool in diagnosing and differentiating causes of early pubertal occurrences. Utility of the test can be limited in some instances, however, including the early phases of pubertal hypothalamic-pituitary-gonadal axis activation, in girls showing commonly overlapping pictures, and in obese children due to excess circulating estrogen that suppresses luteinizing hormone (LH). A lack of consistent baseline and stimulated gonadotropin cutoffs observed in different studies also contributes to limitations in testing. Nevertheless, early detection of true pathological causes for pubertal disorders is needed to allow prompt treatment and better prognosis. While basal LH can be beneficial as a good screening tool for detecting pubertal disorder, it does not preclude the need for GnRH testing. The aim of this review was to highlight the role of GnRH stimulation tests and varying testing cutoffs in diagnosis of precocious puberty and its classification.
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Registered trials
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