Evidence map›Paper›PMID 32871627›Full record

ArticleEuropean journal of haematology2020

Concordance in survival among first-degree relatives diagnosed with indolent lymphoid malignancies including chronic lymphocytic leukemia.

Fredrik Baecklund, Sara Ekberg, Richard Rosenquist, Johan Askling, Sandra Eloranta, Karin E Smedby

Open access · hybridAbstract read
In one paragraph

Article in European journal of haematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fredrik BaecklundDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-1333-2912
Sara EkbergDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
Richard RosenquistDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Johan AsklingDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
Sandra ElorantaDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-5806-0573
Karin E SmedbyDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital · SEKarolinska Institutet · SE

Funding

Cancerfonden CAN 2017/513Karolinska Institutet
6 · The paper itself

Abstract

objectivesTo investigate concordance in survival time among first-degree relatives with lymphoid malignancies.

methodsBy linkage of national Swedish registers, we identified 66 430 patients diagnosed with a lymphoid malignancy 1958-2016 with information on first-degree relationships and follow-up until 2017. Among these, we identified pairs of first-degree relatives with any (N = 3326) or a similar (N = 690) lymphoid malignancy subtype. We defined survival in the first-degree relative as good, expected, or poor based on tertiles of deviance residuals from a multivariable Cox regression model. Next, we used Cox regression to estimate hazard ratios (HR) of death with 95% confidence intervals (CI) among patients, using the survival of their first-degree relative as exposure and adjusting for confounders.

resultsThere was no concordance in survival among first-degree relatives with any lymphoid malignancy (HR

conclusionOur results support a role of inherited factors in the outcome of indolent lymphoma, including chronic lymphocytic leukemia.

Indexed as

Nuclear FamilyAdolescentAdultAgedAged, 80 and overCause of DeathChildChild, PreschoolComorbidityFemaleFollow-Up StudiesHumansInfantInfant, NewbornLeukemia, Lymphocytic, Chronic, B-CellLymphoproliferative Disordersfamily historyfirst-degree relativelymphoid malignancysurvival

Identifiers

PMID32871627
PMCPMC7702025
OpenAlexW3081573129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.