Evidence map›Paper›PMID 32871201›Full record

ReviewAdvanced drug delivery reviews2020

Recent trends in protein and peptide-based biomaterials for advanced drug delivery.

Anastasia Varanko, Soumen Saha, Ashutosh Chilkoti

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed.

  1. Decoding Cytoskeletal Mechanobiology with Tunable Microenvironments.ACS biomaterials science & engineering · 2026
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anastasia VarankoDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Soumen SahaDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA. Electronic address: chilkoti@duke.edu.

Funding

Genetically Encoded Smart Biohybrid MaterialsR35GM127042 · NIGMS · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2018 to 2022
$2.2M
A novel sustained-release immunotoxin for treatment of glioblastoma multiformeR21CA237705 · NCI · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2019 to 2020
$372k
NCI NIH HHS R21 CA237705NIGMS NIH HHS R35 GM127042
6 · The paper itself

Abstract

Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity. These biomolecules have been used to develop a host of drug delivery platforms, such as peptide- and protein-drug conjugates, injectable particles, and drug depots to deliver small molecule drugs, therapeutic proteins, and nucleic acids. In this review, we discuss progress in engineering the architecture and biological functions of peptide-based biomaterials -naturally derived, chemically synthesized and recombinant- with a focus on the molecular features that modulate their structure-function relationships for drug delivery.

Indexed as

Drug Delivery SystemsAnimalsBiocompatible MaterialsHumansPeptidesProteinsTranslational Research, BiomedicalBiocompatible MaterialsPeptidesProteinsBioinspired materialsDrug deliveryHierarchical self-assemblyPolypeptidesRecombinant proteins

Identifiers

PMID32871201
PMCPMC7456198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.