ReviewNeuron2020
How Can Hearing Loss Cause Dementia?
Review in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 220 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Listen Carefully: An Exploratory Study of the Association Between Listening Effort and Cognitive Function
Chemotherapy-Induced Hearing Loss and Health Inequality
Who cites it
220 citing papers in PubMed, 7 syntheses or guidelines pooled it, 353 citations in OpenAlex.
- Hearing aids for mild to moderate hearing loss in adults.The Cochrane database of systematic reviews · 2026Pooled it
- Relationship Between Clusters of Multimorbidity and Dementia Risk: A Systematic Review.International journal of geriatric psychiatry · 2025Pooled it
- The association between dual sensory impairment and dementia: a meta-analysis and systematic review of the literature.Age and ageing · 2025Pooled it
- Pooled it
- Telomere Length and Hearing Loss: A Two-Sample Mendelian Randomization.International journal of environmental research and public health · 2022Pooled it
- Brain Morphological Modifications in Congenital and Acquired Auditory Deprivation: A Systematic Review and Coordinate-Based Meta-Analysis.Frontiers in neuroscience · 2022Pooled it
- Population Attributable Fractions for Modifiable Risk Factors of Incident Dementia in Cognitively Normal and Mild Cognitively Impaired Older Adults: Data from Two Cohort Studies.Journal of Alzheimer's disease : JAD · 2022Pooled it
- Auditory Processing but Not Peripheral Hearing Differs Between Older Adults With and Without Mild Cognitive Impairment.American journal of audiology · 2024Trial
- Age at Fitting Affected Unilateral Versus Bilateral Hearing Aids Choice in Asymmetric Hearing Loss.The journal of international advanced otology · 2023Trial
- Comorbidities and health-care use prior to early-onset Alzheimer's disease: A population-based case-control study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Relationships Among Hearing, Auditory Processing, and Cognition: A Study of Older Adults.Audiology research · 2026Article
- Modifiable Risk Factors for Dementia in Older Patients Receiving Primary Care: A Retrospective Observational Study.Cureus · 2026Article
- Embodied Approach to Autobiographical Recall Disorders in Alzheimer's Disease.Neuropsychology review · 2026Review
- Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP).Alzheimer's research & therapy · 2026Article
- Temporal sequencing of sensory impairments and frailty reveals vulnerability-dependent dementia risk.Research square · 2026Article
- Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms.Biomolecules · 2026Review
- Speech-In-Noise Perception in Alzheimer's Disease and Primary Progressive Aphasia.European journal of neurology · 2026Article
- The Genetic and Transcriptomic Nexus of Age-Related Hearing Loss and Alzheimer's Disease.Genes · 2026Article
- A Global Burden Perspective on Obstructive Sleep Apnea, Hearing Loss, and Early-Onset Cognitive Decline.Neurology international · 2026Review
- Hearing Loss and Dementia: Risk Factor, Early Marker, or Both?Healthcare (Basel, Switzerland) · 2026Review
160 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this relationship. These bases include a common pathology affecting the ascending auditory pathway and multimodal cortex, depletion of cognitive reserve due to an impoverished listening environment, and the occupation of cognitive resources when listening in difficult conditions. We also put forward an alternate mechanism, drawing on new insights into the role of the medial temporal lobe in auditory cognition. In particular, we consider how aberrant activity in the service of auditory pattern analysis, working memory, and object processing may interact with dementia pathology in people with hearing loss. We highlight how the effect of hearing interventions on dementia depends on the specific mechanism and suggest avenues for work at the molecular, neuronal, and systems levels to pin this down.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.