ArticleThe Journal of infectious diseases2021
Rates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- HPV vaccination among seropositive, DNA negative cohorts: a systematic review & meta-analysis.Journal of gynecologic oncology · 2022Pooled it
- The Microbiome-Mitochondria-Extracellular Vesicle Axis in HPV Persistence and Cervical Carcinogenesis.Genes · 2026Review
- Reduced age-wise disparity in estimated cervical cancer screening participation rates after applying hysterectomy correction: a population-based cross-sectional study.BMC women's health · 2026Article
- Impact of Single- Versus Multiple-Type HPV Infections on Cervical Cytological and Histological Abnormalities: The Dominant Oncogenic Potential of HPV16 Single-Type Infections.Diagnostics (Basel, Switzerland) · 2025Article
- Estimated Cancer Risk in Females Who Meet the Criteria to Exit Cervical Cancer Screening.JAMA network open · 2025Article
- High rate of persistent HPV detection after diagnostic cervical excision in older screen-positive women.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Human Papillomavirus Perceptions, Vaccine Uptake, and Sexual Risk Factors in Students Attending a Large Public Midwestern University.Vaccines · 2024Article
- Human Papillomavirus and Associated Cancers: A Review.Viruses · 2024Review
- Incidence of oncogenic HPV infection in women with and without mental illness: A population-based cohort study in Sweden.PLoS medicine · 2024Article
- The human Papillomavirus twilight zone - Latency, immune control and subclinical infection.Tumour virus research · 2023Review
- Effect of Test History at Ages 50-64 on Later Cervical Cancer Risk: A Population-based Case-control Study.Cancer research communications · 2023Article
- Association of plasma aflatoxin with persistent detection of oncogenic human papillomaviruses in cervical samples from Kenyan women enrolled in a longitudinal study.BMC infectious diseases · 2023Article
- HPV and vaginal microecological disorders in infertile women: a cross-sectional study in the Chinese population.Virology journal · 2022Article
- Evidence of latent HPV infection in older Danish women with a previous history of cervical dysplasia.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Article
- Persistence and clearance of high-risk human papillomavirus and cervical dysplasia at 1 year in women living with human immunodeficiency virus: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- A National Survey of Obstetrician/Gynecologists' Knowledge, Attitudes, and Beliefs Regarding Adult Human Papillomavirus Vaccination.Journal of women's health (2002) · 2021Article
- Gut Helminth Infection-Induced Immunotolerance and Consequences for Human Papillomavirus Persistence.The American journal of tropical medicine and hygiene · 2021Review
- It's time to re-evaluate cervical Cancer screening after age 65.Gynecologic oncology · 2021Review
- A proposed new generation of evidence-based microsimulation models to inform global control of cervical cancer.Preventive medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundUnderstanding the source of newly detected human papillomavirus (HPV) in middle-aged women is important to inform preventive strategies, such as screening and HPV vaccination.
methodsWe conducted a prospective cohort study in Baltimore, Maryland. Women aged 35-60 years underwent HPV testing and completed health and sexual behavior questionnaires every 6 months over a 2-year period. New detection/loss of detection rates were calculated and adjusted hazard ratios were used to identify risk factors for new detection.
resultsThe new and loss of detection analyses included 731 women, and 104 positive for high-risk HPV. The rate of new high-risk HPV detection was 5.0 per 1000 woman-months. Reporting a new sex partner was associated with higher detection rates (adjusted hazard ratio, 8.1; 95% confidence interval, 3.5-18.6), but accounted only for 19.4% of all new detections. Among monogamous and sexually abstinent women, new detection was higher in women reporting ≥5 lifetime sexual partners than in those reporting <5 (adjusted hazard ratio, 2.2; 95% confidence interval, 1.2-4.2).
conclusionAlthough women remain at risk of HPV acquisition from new sex partners as they age, our results suggest that most new detections in middle-aged women reflect recurrence of previously acquired HPV.
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