ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Household Transmission of Carbapenemase-producing Enterobacterales in Ontario, Canada.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Transmission of carbapenemase-producing Enterobacter in Ontario, Canada: a retrospective genomic analysis.Emerging microbes & infections · 2026Article
- Review
- Community Outbreak of OXA-48-Producing Escherichia coli Linked to Food Premises, New Zealand, 2018-2022.Emerging infectious diseases · 2025Review
- Gastrointestinal carriage of carbapenemase-producing enterobacterales among inpatient and outpatient children in Kenya.Scientific reports · 2024Article
- [Real-time rectal swab Xpert Carba-R assay for early warning of CRO bloodstream infection in patients undergoing hematopoietic stem cell transplant: a clinical feasibility study].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Article
- Healthcare as a driver, reservoir and amplifier of antimicrobial resistance: opportunities for interventions.Nature reviews. Microbiology · 2024Review
- Carbapenemase-producing enterobacterales colonisation status does not lead to more frequent admissions: a linked patient study.Antimicrobial resistance and infection control · 2024Article
- Article
- Intestinal Colonization of Preterm Neonates with Carbapenem Resistant Enterobacteria at Hospital Discharge.Antibiotics (Basel, Switzerland) · 2023Article
- Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales.Nature communications · 2022Article
- Genomic Epidemiology of Carbapenemase-ProducingAntimicrobial agents and chemotherapy · 2021Article
Corrections and comments
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Authors and funding
30 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundData on household transmission of carbapenemase-producing Enterobacterales (CPE) remain limited. We studied risk of CPE household co-colonization and transmission in Ontario, Canada.
methodsWe enrolled CPE index cases (identified via population-based surveillance from January 2015 to October 2018) and their household contacts. At months 0, 3, 6, 9, and 12, participants provided rectal and groin swabs. Swabs were cultured for CPE until September 2017, when direct polymerase chain reaction (PCR; with culture of specimens if a carbapenemase gene was detected) replaced culture. CPE risk factor data were collected by interview and combined with isolate whole-genome sequencing to determine likelihood of household transmission. Risk factors for household contact colonization were explored using a multivariable logistic regression model with generalized estimating equations.
resultsNinety-five households with 177 household contacts participated. Sixteen (9%) household contacts in 16 (17%) households were CPE-colonized. Household transmission was confirmed in 3/177 (2%) cases, probable in 2/177 (1%), possible in 9/177 (5%), and unlikely in 2/177 (1%). Household contacts were more likely to be colonized if they were the index case's spouse (odds ratio [OR], 6.17; 95% confidence interval [CI], 1.05-36.35), if their index case remained CPE-colonized at household enrollment (OR, 7.00; 95% CI, 1.92-25.49), or if they had at least 1 set of specimens processed after direct PCR was introduced (OR, 6.46; 95% CI, 1.52-27.40).
conclusionsNine percent of household contacts were CPE-colonized; 3% were a result of household transmission. Hospitals may consider admission screening for patients known to have CPE-colonized household contacts.
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