ArticleThe Journal of clinical endocrinology and metabolism2020
Race, Ancestry, and Vitamin D Metabolism: The Multi-Ethnic Study of Atherosclerosis.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Performance of urinary vitamin D-binding protein in diabetic kidney disease: a meta-analysis.Renal failure · 2023Pooled it
- Clinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis.The American journal of clinical nutrition · 2022Trial
- Evaluation of correlations between serum and urinary vitamin D metabolites using LC-MS/MS.Bioscience reports · 2026Article
- Genomic ancestry and diversity in individuals with type 1 diabetes from Brazil and Portugal: a descriptive analysis.Diabetology & metabolic syndrome · 2026Article
- Association between thyroid cancer and vitamin D deficiency.Chinese medical journal · 2026Article
- Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Maternal serum vitamin D levels and preeclampsia among Kenyan pregnant women: A matched case-control study.PloS one · 2026Article
- Vitamin D Levels During Pregnancy and Dental Caries in Offspring.JAMA network open · 2025Article
- Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.Medicine · 2025Article
- Determinants and sequelae of smoking: prevalence, incidence, and cessation among male adults in Abu dhabi, United Arab Emirates - a retrospective cohort study.BMC public health · 2025Article
- Article
- Metallomic profiles of pregnant women living with obesity in the UK: a secondary analysis of UPBEAT.Metallomics : integrated biometal science · 2025Article
- The Interplay Between Vitamin D Deficiency, Iron Status, and Anemia Risk in Moroccan Women of Reproductive Age: A Cross-Sectional Analysis.Epidemiologia (Basel, Switzerland) · 2024Article
- Disease Risk Score Derivation and Validation in Abu Dhabi, United Arab Emirates: A Retrospective Cohort Study.Journal of the American Heart Association · 2024Article
- Precision Renal Osteodystrophy: What's Race Got to do With It?Current osteoporosis reports · 2024Review
- Vitamin D-Do Diet Recommendations for Health Remain Strong?Current osteoporosis reports · 2024Review
- Prevalence of low vitamin D levels among older US Asian and Pacific Islander adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Exploring the unique association between high-density lipoprotein cholesterol and vitamin D deficiency in adults aged 20-59: findings based on the NHANES database.BMC endocrine disorders · 2024Article
- Vitamin D and Depression: Racial Differences Suggest an Alternate Biomarker.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Perspective: Nutrition Health Disparities Framework: A Model to Advance Health Equity.Advances in nutrition (Bethesda, Md.) · 2024Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
Abstract
contextA comprehensive characterization of racial/ethnic variations in vitamin D metabolism markers may improve our understanding of differences in bone and mineral homeostasis and the risk of vitamin D-related diseases.
objectiveDescribe racial/ethnic differences in vitamin D metabolism markers and their associations with genetic ancestry. DESIGN, SETTING,
participantsIn a cross-sectional study within the Multi-Ethnic Study of Atherosclerosis (MESA), we compared a comprehensive panel of vitamin D metabolism markers across self-reported racial/ethnic groups of Black (N = 1759), White (N = 2507), Chinese (N = 788), and Hispanic (N = 1411). We evaluated associations of proportion African and European ancestry with this panel of markers in Black and Hispanic participants using ancestry informative markers. Latent class analysis evaluated associations between patterns of vitamin D measurements with race/ethnicity.
resultsCompared with Black participants, White participants had significantly higher serum concentrations of 25-hydroxyvitamin D and fibroblast growth factor-23; lower concentrations of parathyroid hormone and 1,25-dihydroxyvitamin D; circulating vitamin D metabolite ratios suggesting lower CYP27B1 and higher CYP24A1 activity; higher urinary concentrations of calcium and phosphorus with higher urinary fractional excretion of phosphorus; and differences in vitamin D binding globulin haplotypes. Higher percent European ancestry was associated with higher 25-hydroxyvitamin D and lower parathyroid hormone concentrations among Black and Hispanic participants. Latent classes defined by vitamin D measurements reflected these patterns and differed significantly by race/ethnicity and ancestry.
conclusionsMarkers of vitamin D metabolism vary significantly by race/ethnicity, may serve to maintain bone and mineral homeostasis across ranges of 25-hydroxyvitamin D production, and be attributable, at least partly, to genetic ancestry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.