Evidence map›Paper›PMID 32869747›Full record

ArticleeLife2020

Activation of astrocytes in hippocampus decreases fear memory through adenosine A

Yulan Li, Lixuan Li, Jintao Wu, Zhenggang Zhu, Xiang Feng, Liming Qin, Yuwei Zhu, Li Sun, Yijun Liu, Zilong Qiu and 2 more

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Hippocampal astrocytic sequences emerge during learning and memory.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Subicular Astrocytes Govern Seizure-Impaired Fear Memory.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Review
  11. Astrocytes as Active Participants in Memory.Journal of neurochemistry · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Enhancement of CaNeuroscience bulletin · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yulan Li *Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lixuan Li *Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jintao WuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhenggang ZhuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiang FengDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Liming QinDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yuwei ZhuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Li SunDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yijun LiuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zilong QiuInstitute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
Shumin DuanDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yan-Qin YuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0002-4378-5931

Funding

CAMS Innovation Fund for Medical Science 2019-I2M-5-057Fundamental Research Funds for the Central Universitues 2019FZA7009National Key Research and Development Program 2016YFA0501000National Key Research and Development Program 2016YFC1306700National Natural Science Foundation of China 31571090National Natural Science Foundation of China 31771167National Natural Science Foundation of China 31970939National Natural Science Foundation of China 81527901National Natural Science Foundation of China 81821091Science and technology Planning Project of Guangdong Province 2018B030331001Science and Technology Planning Project of Guangdong Province 2018B030331001The National Key Research and Development Program 2016YFA0501000The National Key Research and Development Program 2016YFC1306700The Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences 2018PT31041
6 · The paper itself

Abstract

Astrocytes respond to and regulate neuronal activity, yet their role in mammalian behavior remains incompletely understood. Especially unclear is whether, and if so how, astrocyte activity regulates contextual fear memory, the dysregulation of which leads to pathological fear-related disorders. We generated

Indexed as

Receptor, Adenosine A1AnimalsAnxietyAstrocytesBehavior, AnimalFearFemaleHippocampusMaleMemoryOptogeneticsRatsRats, Sprague-DawleyRats, TransgenicReceptor, Adenosine A1adenosine A1 receptorsanxietyastrocytefear memorymemory consolidationneurosciencerat

Identifiers

PMID32869747
PMCPMC7505657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.