ArticleeLife2020
Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Social processing in the amygdala: single-nucleus RNA-sequencing reveals distinct neuronal responses to dominant and subordinate cues.Scientific reports · 2026Article
- Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinct Neuronal Responses to Dominant and Subordinate Cues.Research square · 2026Article
- Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinct Neuronal Responses to Dominant and Subordinate Cues.bioRxiv : the preprint server for biology · 2025Article
- A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis.Science advances · 2025Article
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain.Molecular psychiatry · 2025Article
- Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala.Scientific reports · 2025Article
- Establishing a continuum of cell types in the visual cortex.bioRxiv : the preprint server for biology · 2025Article
- A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior.Current biology : CB · 2025Article
- Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates.Science advances · 2025Article
- Transcriptomic Analysis Corroborates the New Radial Model of the Mouse Pallial Amygdala.Biomolecules · 2025Article
- A nociceptive amygdala-striatal pathway modulating affective-motivational pain.Science advances · 2025Article
- A molecularly defined mPFC-BLA circuit specifically regulates social novelty preference.Science advances · 2025Article
- Biased Information Routing Through the Basolateral Amygdala, Altered Valence Processing, and Impaired Affective States Associated With Psychiatric Illnesses.Biological psychiatry · 2025Review
- Article
- Atypical hippocampal excitatory neurons express and govern object memory.Nature communications · 2025Article
- Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks.Nature neuroscience · 2025Review
- Divergent and subnucleus-specific gene expression responses to chronic stress hormone exposure in the amygdala.Frontiers in molecular neuroscience · 2025Article
- Identification of a stress-responsive subregion of the basolateral amygdala in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation.Neuroscience research · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The basolateral amygdala complex (BLA), extensively connected with both local amygdalar nuclei as well as long-range circuits, is involved in a diverse array of functional roles. Understanding the mechanisms of such functional diversity will be greatly informed by understanding the cell-type-specific landscape of the BLA. Here, beginning with single-cell RNA sequencing, we identified both discrete and graded continuous gene-expression differences within the mouse BLA. Via in situ hybridization, we next mapped this discrete transcriptomic heterogeneity onto a sharp spatial border between the basal and lateral amygdala nuclei, and identified continuous spatial gene-expression gradients within each of these regions. These discrete and continuous spatial transformations of transcriptomic cell-type identity were recapitulated by local morphology as well as long-range connectivity. Thus, BLA excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties. This heterogeneity likely drives pronounced spatial variation in BLA computation and function.
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