ArticleJournal of the American Heart Association2020
Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Social Isolation and Daily Steps Are Associated With Fatigue in Older Women With Cardiovascular Disease: A Secondary Analysis of the MindMoves Trial.Journal of aging and physical activity · 2026Trial
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Cardiovascular risk and cognitive performance: A population-based cross-sectional study (NEDICES2-RISK).PloS one · 2026Article
- The Prognostic Impact of Paroxysmal Atrial Fibrillation on Disability Severity and Activity of Daily Living After Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2025Article
- Cardiovascular Health, Assessed by Life's Essential 8, Is Associated with Lower Risk of Disability Among Older, Community-Dwelling Men and Women.European journal of investigation in health, psychology and education · 2025Article
- Healthy ageing in older adults with cardiovascular disease.European heart journal · 2025Review
- Refined carbohydrates and the overfat pandemic: implications for brain health and public health policy.Frontiers in public health · 2025Review
- Longitudinal associations of cardiovascular health and vascular events with incident dementia.Stroke and vascular neurology · 2024Article
- Cardiovascular risk burden and disability: findings from the International Mobility in Aging Study (IMIAS).Journal of geriatric cardiology : JGC · 2024Article
- Does Incident Cardiovascular Disease Lead to Greater Odds of Functional and Cognitive Impairment? Insights From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Contribution of life course cardiovascular risk factors to racial disparities in dementia incidence.Frontiers in dementia · 2023Article
- Rethinking COVID-19 and Beyond: Prevention, Remedies, and Recovery.Frontiers in public health · 2022Article
- Associations of physical activity with cognitive function and daily physical function among Chinese individuals with heart disease: A cross-sectional study.Frontiers in public health · 2022Article
- Health-related factors leading to disabilities in Korea: Survival analysis.Frontiers in public health · 2022Article
- Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline.Journal of the American Heart Association · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Background Cardiovascular risk burden has been linked to cardiovascular disease (CVD) and cognitive decline, but its association with disability is unclear. We aimed to examined the association of cardiovascular risk burden assessed by the Framingham general cardiovascular risk score (FGCRS) with the risk and progression of disability and estimated the extent to which CVD and cognitive decline mediate this association. Methods and Results A total of 1480 older adults with no disabilities (mean age=79.32±7.38 years) from the Rush Memory and Aging Project were followed for up to 21 years. FGCRS at baseline was calculated and categorized into tertiles. Disability was assessed annually with activities of daily living. The number of CVDs was calculated by summing up the CVD events. Global cognitive function was assessed annually with a battery of 19 tests. Data were analyzed using the Cox model, linear mixed effects model, and mediation analysis. At the end of the follow-up, 713 (48.2%) participants developed disability. Compared with the lowest tertile of the FGCRS, the multiadjusted hazards ratios of disability were 1.34 (95% CI, 1.11-1.62) for the highest tertile. In addition, the highest FGCRS was associated with a change in activities of daily living score over time (β=0.057; 95% CI, 0.021-0.093). The association between FGCRS and change in activities of daily living was 13.8% mediated by the accumulation of CVDs and 25.1% by cognitive decline, respectively. Conclusions Higher cardiovascular risk burden increased the risk of disability and accelerated its progression over time. CVD accumulation and cognitive decline may partially mediate the association.
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