Evidence map›Paper›PMID 32869481›Full record

ArticleJournal of the International AIDS Society2020

Directed and target focused multi-sectoral adolescent HIV prevention: Insights from implementation of the 'DREAMS Partnership' in rural South Africa.

Natsayi Chimbindi, Isolde Birdthistle, Sian Floyd, Guy Harling, Nondumiso Mthiyane, Thembelihle Zuma, James R Hargreaves, Janet Seeley, Maryam Shahmanesh

Open access · goldAbstract read
In one paragraph

Article in Journal of the International AIDS Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 70 citations in OpenAlex.

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  11. Experiences of adolescent girls and young women of oral PrEP uptake in rural KwaZulu-Natal.African journal of primary health care & family medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Natsayi ChimbindiAfrica Health Research Institute, Mtubatuba, South Africa.ORCID 0000-0003-3125-978X
Isolde BirdthistleLondon School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0001-5742-6588
Sian FloydLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Guy HarlingAfrica Health Research Institute, Mtubatuba, South Africa.ORCID 0000-0001-6604-491X
Nondumiso MthiyaneAfrica Health Research Institute, Mtubatuba, South Africa.
Thembelihle ZumaAfrica Health Research Institute, Mtubatuba, South Africa.
James R HargreavesLondon School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0002-3509-3572
Janet SeeleyAfrica Health Research Institute, Mtubatuba, South Africa.ORCID 0000-0002-0583-5272
Maryam ShahmaneshAfrica Health Research Institute, Mtubatuba, South Africa.ORCID 0000-0001-7129-8535
Africa Health Research Institute · ZALondon School of Hygiene & Tropical Medicine · GBHarvard University · US

Funding

Maximizing combination HIV prevention, uptake and retention by adolescent girls and young womenR01MH114560 · NIMH · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI SHAHMANESH, MARYAM · 2017 to 2023
$2.0M
Gates Foundation OPP1136774Marie Curie FP7/2007-2013Medical Research Council MR/R010161/1NIH HHS 5R01MH114560-03NIMH NIH HHS R01 MH114560Wellcome TrustWellcome Trust 082384/Z/07/Z
6 · The paper itself

Abstract

introductionThe "DREAMS Partnership" promotes a multi-sectoral approach to reduce adolescent girls and young women's (AGYW) vulnerability to HIV in sub-Saharan Africa. Despite widespread calls to combine structural, behavioural and biomedical HIV prevention interventions, this has not been delivered at scale. In this commentary, we reflect on the two-year rollout of DREAMS in a high HIV incidence, rural and poor community in northern KwaZulu-Natal, South Africa to critically appraise the capacity for a centrally co-ordinated and AGYW-focused approach to combination HIV prevention to support sustainable development for adolescents. DISCUSSION: DREAMS employed a directed target-focused approach in which local implementing partners were resourced to deliver defined packages to AGYW in selected geographical areas over two years. We argue that this approach, with high-level oversight by government and funders, enabled the rapid roll-out of ambitious multi-sectoral HIV prevention for AGYW. It was most successful at delivering multiple interventions for AGYW when it built on existing infrastructure and competencies, and/or allocated resources to address existing youth development concerns of the community. The approach would have been strengthened if it had included a mechanism to solicit and then respond to the concerns of young women, for example gender-related norms and how young women experience their sexuality, and if this listening was supported by versatility to adapt to the social context. In a context of high HIV vulnerability across all adolescents and youth, an over-emphasis on targeting specific groups, whether geographically or by risk profile, may have hampered acceptability and reach of the intervention. Absence of meaningful engagement of AGYW in the development, delivery and leadership of the intervention was a lost opportunity to achieve sustainable development goals among young people and shift gender-norms.

conclusionsCentrally directed and target-focused scale-up of defined packages of HIV prevention across sectors was largely successful in reaching AGYW in this rural South African setting rapidly. However, to achieve sustainable and successful long-term youth development and transformation of gender-norms there is a need for greater adaptability, economic empowerment and meaningful engagement of AGYW in the development and delivery of interventions. Achieving this will require sustained commitment from government and funders.

Indexed as

AdolescentAdultFemaleHIV InfectionsHumansIncidenceRisk FactorsRural HealthSexual BehaviorSouth AfricaYoung Adultadolescent girls and young womenHIVholisticimplementationinterventionslayering

Identifiers

PMID32869481
PMCPMC7459161
OpenAlexW3082355087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.