Evidence map›Paper›PMID 32869443›Full record

ArticleJournal of cellular and molecular medicine2020

Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels.

Masako Honda, Yoshiya Ito, Kyoko Hattori, Kanako Hosono, Kazuki Sekiguchi, Kazutake Tsujikawa, Nobuya Unno, Masataka Majima

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Masako HondaDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Yoshiya ItoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.ORCID 0000-0001-5258-2098
Kyoko HattoriDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Kanako HosonoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Kazuki SekiguchiDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Kazutake TsujikawaLaboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Nobuya UnnoDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Sagamihara, Japan.
Masataka MajimaDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
National Sagamihara Hospital · JPKitasato University · JPKanagawa Institute of Technology · JPOsaka University of Pharmaceutical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroimmune interactions are involved in the development of endometriosis. Here, we examined the role of a neuropeptide, calcitonin gene-related peptide (CGRP), and its receptor, receptor activity-modifying protein (RAMP) 1, in growth of endometrial tissues and the formation of blood and lymphatic vessels in a mouse ectopic endometrial transplantation model. Endometrial fragments from donor wild-type (WT) mice transplanted into the peritoneal wall of recipient WT mice grew with increased density of blood and lymphatic vessels. When tissues from RAMP1-deficient (RAMP1

Indexed as

LymphangiogenesisNeovascularization, PhysiologicAnimalsBlood VesselsCalcitonin Gene-Related PeptideCells, CulturedCytokinesEndometriosisFemaleFibroblastsLymphatic VesselsMacrophagesMice, KnockoutPeptide FragmentsReceptor Activity-Modifying Protein 1Signal TransductionCalcitonin Gene-Related Peptidecalcitonin gene-related peptide (8-37)CytokinesPeptide FragmentsReceptor Activity-Modifying Protein 1Vascular Endothelial Growth Factor AangiogenesisCGRPendometriosislymphangiogenesisRAMP1

Identifiers

PMID32869443
PMCPMC7578853
OpenAlexW3082121332

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.