Evidence map›Paper›PMID 32869432›Full record

ArticleMolecular reproduction and development2020

Fecundity is impaired in a mouse model of osteogenesis imperfecta.

Arin K Oestreich, Jenna A DeCata, Janae D Akers, Charlotte L Phillips, Laura C Schulz

Abstract readLetter
In one paragraph

Article in Molecular reproduction and development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arin K OestreichDepartment of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri.
Jenna A DeCataDepartment of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri.
Janae D AkersDepartment of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri.
Charlotte L PhillipsDepartments of Biochemistry and Child Health, University of Missouri, Columbia, Missouri.ORCID 0000-0002-7761-3783
Laura C SchulzDepartment of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri.ORCID 0000-0001-8722-6616

Funding

Maternal Anti-myostatin (GDF8) Therapy to Enhance Offspring Musculoskeletal Health in Mouse Models of Osteogenesis ImperfectaR21AR077813 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI PHILLIPS, CHARLOTTE L · 2020 to 2021
$368k
NIAMS NIH HHS R21 AR077813
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI), or brittle bone disease, is most often caused by mutations in genes encoding type I collagen or proteins that process it. Women with OI have a small, but significant increase in risk of serious pregnancy complications including uterine rupture. Here, the OI mouse, Col1a2

Indexed as

AnimalsCollagen Type IDisease Models, AnimalFemaleFertilityFetal ViabilityHumansInfertility, FemaleLitter SizeMaleMiceMice, TransgenicMutationOsteogenesis ImperfectaPregnancyPregnancy, High-RiskCol1a2 protein, mouseCollagen Type Icollagenosteogenesis imperfectapregnancy complicationsuterus

Identifiers

PMID32869432
PMCPMC8173670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.