ArticleAnnals of neurology2020
Functional Connectivity Decreases with Metabolic Stress in Sickle Cell Disease.
Article in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Regional brain age is decreased in children with sickle cell anemia.Blood advances · 2026Article
- Investigating Disruptions in Information Flow due to Sickle Cell Disease Using Granger Causality.Human brain mapping · 2025Article
- Brain Age Modeling and Cognitive Outcomes in Young Adults With and Without Sickle Cell Anemia.JAMA network open · 2025Article
- Reversibility of Cognitive Deficits and Functional Connectivity With Transfusion in Children With Sickle Cell Disease.Neurology · 2024Article
- Decline in Processing Speed Tells Only Half the Story: Developmental Delay in Children Living with Sickle Cell Disease.Children (Basel, Switzerland) · 2024Article
- Infrared Spectroscopy: A New Frontier in Hematological Disease Diagnosis.International journal of molecular sciences · 2023Review
- Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia.Blood advances · 2023Article
- The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.Hematology/oncology clinics of North America · 2022Review
- Neurocognitive Changes in Sickle Cell Disease: A Comprehensive Review.Annals of neurosciences · 2022Review
- Cerebral oxygen metabolic stress is increased in children with sickle cell anemia compared to anemic controls.American journal of hematology · 2022Article
- Quantification of Silent Cerebral Infarction on High-Resolution FLAIR and Cognition in Sickle Cell Anemia.Frontiers in neurology · 2022Article
- Cerebral and skeletal muscle tissue oxygenation during exercise challenge in children and young adults with sickle cell anaemia.British journal of haematology · 2022Article
- Cerebral Oxygen Metabolic Stress, Microstructural Injury, and Infarction in Adults With Sickle Cell Disease.Neurology · 2021Article
- Brain Health in Children with Type 1 Diabetes: Risk and Protective Factors.Current diabetes reports · 2021Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveChildren with sickle cell disease (SCD) experience cognitive deficits even when unaffected by stroke. Using functional connectivity magnetic resonance imaging (MRI) as a potential biomarker of cognitive function, we tested our hypothesis that children with SCD would have decreased functional connectivity, and that children experiencing the greatest metabolic stress, indicated by elevated oxygen extraction fraction, would have the lowest connectivity.
methodsWe prospectively obtained brain MRIs and cognitive testing in healthy controls and children with SCD.
resultsWe analyzed data from 60 participants (20 controls and 40 with sickle cell disease). There was no difference in global cognition or cognitive subdomains between cohorts. However, we found decreased functional connectivity within the sensory-motor, lateral sensory-motor, auditory, salience, and subcortical networks in participants with SCD compared with controls. Further, as white matter oxygen extraction fraction increased, connectivity within the visual (p = 0.008, parameter estimate = -0.760 [95% CI = -1.297, -0.224]), default mode (p = 0.012, parameter estimate = -0.417 [95% CI = -0.731, -0.104]), and cingulo-opercular (p = 0.009, parameter estimate = -0.883 [95% CI = -1.517, -0.250]) networks decreased.
interpretationWe conclude that there is diminished functional connectivity within these anatomically contiguous networks in children with SCD compared with controls, even when differences are not seen with cognitive testing. Increased white matter oxygen extraction fraction was associated with decreased connectivity in select networks. These data suggest that elevated oxygen extraction fraction and disrupted functional connectivity are potentially presymptomatic neuroimaging biomarkers for cognitive decline in SCD. ANN NEUROL 2020;88:995-1008.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.