Evidence map›Paper›PMID 32869318›Full record

ArticleThe Journal of comparative neurology2021

Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration.

Allysa Warling, Riri Uchida, Hyunsoo Shin, Coby Dodelson, Madeleine E Garcia, N Beckett Shea-Shumsky, Sarah Svirsky, Morgan Pothast, Hunter Kelley, Cynthia M Schumann and 7 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Allysa WarlingLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.
Riri UchidaLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.
Hyunsoo ShinLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.
Coby DodelsonLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.
Madeleine E GarciaLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.
N Beckett Shea-ShumskyLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.
Sarah SvirskyDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Morgan PothastDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Hunter KelleyDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Cynthia M SchumannDepartment of Psychiatry and Behavioral Sciences, University of California, Sacramento, California, USA.ORCID 0000-0002-3763-7596
Christine BrzezinskiDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Melissa D BaumanDepartment of Psychiatry and Behavioral Sciences, University of California, Sacramento, California, USA.
Allyson AlexanderDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Ann C McKeeDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Thor D SteinDepartment of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Matthew SchallLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.
Bob JacobsLaboratory of Quantitative Neuromorphology, Neuroscience Program, Department of Psychology, Colorado College, Colorado Springs, Colorado, USA.ORCID 0000-0002-4662-3401
Colorado College · USBoston University · USCalifornia State University, Sacramento · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical SyndromesU54NS115266 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2019 to 2023
$10.3M
CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo ImagingU01NS086659 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2014 to 2017
$6.1M
Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and NeuroinflammationRF1AG057902 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2017 to 2017
$4.1M
The neuropathology of mild traumatic brain injury in Alzheimer's diseaseI01CX001038 · VA · EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL · PI STEIN, THOR · 2015 to 2022
–
CSRD VA I01 CX001038NIA NIH HHS P30 AG013846NIA NIH HHS RF1 AG057902NINDS NIH HHS U01 NS086659NINDS NIH HHS U54 NS115266
6 · The paper itself

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (McKee et al., 2016, Acta Neuropathologica, 131, 75-86). Although many pathological and assumed clinical correlates of CTE have been well characterized, its effects on cortical dendritic arbors are still unknown. Here, we quantified dendrites and dendritic spines of supragranular pyramidal neurons in tissue from human frontal and occipital lobes, in 11 cases with (M

Indexed as

AgedAged, 80 and overChronic Traumatic EncephalopathyDendritesHumansMalechronic traumatic encephalopathydegenerationdendritesdysfunctionrepetitive head impactsRRID:SCR_001775

Identifiers

PMID32869318
PMCPMC8554981
OpenAlexW3082749368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.