Evidence map›Paper›PMID 32869182›Full record

ArticleMolecular neurobiology2020

Advances in the Understanding of Oxaliplatin-Induced Peripheral Neuropathy in Mice: 7-Chloro-4-(Phenylselanyl) Quinoline as a Promising Therapeutic Agent.

Angélica S Reis, Jaini J Paltian, William B Domingues, Diogo L R Novo, Gabriel P Costa, Diego Alves, Vinicius F Campos, Marcia F Mesko, Cristiane Luchese, Ethel A Wilhelm

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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  9. The Therapeutic Potential of Antioxidants in Chemotherapy-Induced Peripheral Neuropathy: Evidence from Preclinical and Clinical Studies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Angélica S ReisPrograma de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.
Jaini J PaltianPrograma de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.
William B DominguesPrograma de Pós-graduação em Biotecnologia, Laboratório de Genômica Estrutural, Biotecnologia, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.
Diogo L R NovoPrograma de Pósgraduação em Química, Laboratório de Controle de Contaminantes em Biomateriais, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, CEP 96010-900, Brazil.
Gabriel P CostaPrograma de Pós-graduação em Química, Laboratório de Síntese Orgânica Limpa, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.
Diego AlvesPrograma de Pós-graduação em Química, Laboratório de Síntese Orgânica Limpa, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.
Vinicius F CamposPrograma de Pós-graduação em Biotecnologia, Laboratório de Genômica Estrutural, Biotecnologia, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil.
Marcia F MeskoPrograma de Pósgraduação em Química, Laboratório de Controle de Contaminantes em Biomateriais, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, CEP 96010-900, Brazil.
Cristiane LuchesePrograma de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil. cristiane_luchese@yahoo.com.br.
Ethel A WilhelmPrograma de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas, RS, CEP 96010-900, Brazil. ethelwilhelm@yahoo.com.br.ORCID http://orcid.org/0000-0002-2875-9962
Universidade Federal de Pelotas · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 429859/2018-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001FAPERGS 16/2551-0000240-1Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 17/2551-0001013-2
6 · The paper itself

Abstract

In this study, the deposition of platinum in oxaliplatin (OXA)-exposed mice and the effects of the oxidative damage on the central nervous system were investigated. The relationship between the reactive species (RS) levels as well as the expression and activity of enzymes, such as catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and acetylcholinesterase (AChE), in the development of peripheral neuropathy after OXA exposure, was evidenced. The effects of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) on OXA-induced peripheral neuropathy was also investigated. Swiss mice received OXA (10 mg kg

Indexed as

AcetylcholinesteraseAnimalsAntioxidantsCatalaseExploratory BehaviorGlutathione PeroxidaseMaleMiceMotor ActivityOxaliplatinOxidative StressPeripheral Nervous System DiseasesQuinolinesReproducibility of ResultsSpinal CordSuperoxide Dismutase7-chloro-4-(phenylselanyl) quinolineAcetylcholinesteraseAntioxidantsCatalaseGlutathione PeroxidaseOxaliplatinquinolineQuinolinesSuperoxide DismutaseAcetylcholinesteraseNeuropathyOxaliplatinPainPlatinumSelenium

Identifiers

PMID32869182
OpenAlexW3081985269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.