Evidence map›Paper›PMID 32869162›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2020

Efficacy of topical versus intravenous tranexamic acid in spinal deformity.

Karen A Weissmann, Virginie Lafage, Carlos Barrios Pitaque, Renaud Lafage, Francoise M Descazeaux

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05554211 (Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05554211 phase2withdrawnnot on this mapstarted 2022, after this paper: background citation

Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage

TypeinterventionalSponsorNorthwestern UniversityRan2022 to 2024Enrolled0ConditionsBreast Cancer, BRCA MutationArmsTranexamic acid, Normal saline
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Comparative efficacy and safety of different tranexamic acid administration in spine surgery: a network meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Karen A WeissmannEscuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain. kweissmann@mail.ucv.es.ORCID 0000-0003-4263-6704
Virginie LafageDepartment of Surgery, Hospital for Special Surgery, New York, NY, US.
Carlos Barrios PitaqueEscuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.
Renaud LafageDepartment of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, US.
Francoise M DescazeauxHospital Exequiel Gonzalez Cortés, Santiago, Chile.
Hospital for Special Surgery · USValencia Catholic University Saint Vincent Martyr · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare topical tranexamic acid versus intravenous tranexamic acid in reducing intra- and postoperative blood loss and transfusion rate in deformity patients. MATERIALS AND

methodWe performed a retrospective cohort study with posterior fusion deformity patients, between 2009 and 2016. Patients were categorized in 4 groups: "No TXA" (n = 35) if the wound was packed with saline soaked sponges, "IV TXA" (n = 37) the patient received 20 mg/kg bolus at the beginning of the surgery followed by continuous infusion of 1 mg/kg/hr until closure, "Topical TXA" (n = 23) the wound was packed with sponges soaked in 6 g of TXA diluted in a 3 L saline solution, or "Combined TXA" (n = 86) the patient received both IV and topical TXA. The primary outcomes were total, intra- and postoperative blood loss, surgical time, postoperative Ht/Hb, transfusion rates, and duration of drain insertion.

resultsA total of 181 patients were analyzed (78.6% F, 15.08 yo). No differences were found in total and intraoperative blood loss, surgical time, postoperative Ht/Ht, and transfusion rates. "Combined TXA" group had significantly less postoperative bleeding than "no TXA" group (p = 0.022). IV TXA patients (with o/without topical TXA) removed drains one day earlier than the no TXA group (p = 0.002). There were no complications related to the use of tranexamic acid.

conclusionThere is significant decrease in postoperative bleeding in pediatric deformity patients with combined topical and IV tranexamic acid.

Indexed as

Administration, TopicalAntifibrinolytic AgentsBlood Loss, SurgicalBlood TransfusionChildHumansPostoperative HemorrhageRetrospective StudiesTranexamic AcidAntifibrinolytic AgentsTranexamic AcidScoliosisTopicalTranexamic acid

Identifiers

PMID32869162
OpenAlexW3082733077

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.