Evidence map›Paper›PMID 32869069›Full record

Trial reportAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2020

Intubation Setting, Aspiration, and Ventilator-Associated Conditions.

Steven Talbert, Christine Wargo Detrick, Kimberly Emery, Aurea Middleton, Bassam Abomoelak, Chirajyoti Deb, Devendra I Mehta, Mary Lou Sole

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Steven TalbertSteven Talbert is an assistant clinical professor, Christine Wargo Detrick is a doctoral student, and Kimberly Emery is a doctoral candidate, University of Central Florida College of Nursing, Orlando, Florida.
Christine Wargo DetrickSteven Talbert is an assistant clinical professor, Christine Wargo Detrick is a doctoral student, and Kimberly Emery is a doctoral candidate, University of Central Florida College of Nursing, Orlando, Florida.
Kimberly EmerySteven Talbert is an assistant clinical professor, Christine Wargo Detrick is a doctoral student, and Kimberly Emery is a doctoral candidate, University of Central Florida College of Nursing, Orlando, Florida.
Aurea MiddletonAurea Middleton is a clinical research coordinator, Orlando Regional Medical Center, Orlando, Florida.
Bassam AbomoelakBassam Abomoelak is a senior research associate and Chirajyoti Deb is a senior research scientist, Gastrointestinal Translational Laboratory, Arnold Palmer Hospital, Orlando Health, Orlando.
Chirajyoti DebChirajyoti Deb is a senior research scientist, Gastrointestinal Translational Laboratory, Arnold Palmer Hospital, Orlando Health, Orlando.
Devendra I MehtaDevendra I. Mehta is an associate professor at Florida State University and director of the Gastrointestinal Translational Laboratory, Arnold Palmer Hospital for Children, Orlando Health.
Mary Lou SoleMary Lou Sole is dean, Orlando Health Endowed Chair in Nursing, and University of Central Florida Pegasus Professor, University of Central Florida College of Nursing.
University of Central Florida · USArnold Palmer Hospital for Children · USOrlando Regional Medical Center · US

Funding

Duke University Molecular Imaging CenterR24CA092656 · NCI · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2001 to 2006
$3.7M
Oral Suction Intervention to Reduce Aspiration and Ventilator Events: NO-ASPIRATER01NR014508 · NINR · UNIVERSITY OF CENTRAL FLORIDA · PI SOLE, MARY LOU · 2014 to 2017
$2.3M
Small Animal Imaging Resource ProgramU24CA092656 · NCI · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2007 to 2011
$2.2M
NCI NIH HHS R24 CA092656NCI NIH HHS U24 CA092656NINR NIH HHS R01 NR014508
6 · The paper itself

Abstract

backgroundPatients experience endotracheal intubation in various settings with wide-ranging risks for postintubation complications such as aspiration and ventilator-associated conditions.

objectivesTo evaluate associations between intubation setting, presence of aspiration biomarkers, and clinical outcomes.

methodsThis study is a subanalysis of data from the NO-ASPIRATE single-blinded randomized clinical trial. Data were prospectively collected for 513 adult patients intubated within 24 hours of enrollment. Patients with documented aspiration events at intubation were excluded. In the NO-ASPIRATE trial, intervention patients received enhanced oropharyngeal suctioning every 4 hours and control patients received sham suctioning. Tracheal specimens for α-amylase and pepsin tests were collected upon enrollment. Primary outcomes were ventilator hours, lengths of stay, and rates of ventilator-associated conditions.

resultsOf the baseline tracheal specimens, 76.4% were positive for α-amylase and 33.1% were positive for pepsin. Proportions of positive tracheal α-amylase and pepsin tests did not differ significantly between intubation locations (study hospital, transfer from other hospital, or field intubation). No differences were found for ventilator hours or lengths of stay. Patients intubated at another hospital and transferred had significantly higher ventilator-associated condition rates than did those intubated at the study hospital (P = .02). Ventilator-associated condition rates did not differ significantly between patients intubated in the field and patients in other groups.

conclusionsHigher ventilator-associated condition rates associated with interhospital transfer may be related to movement from bed, vehicle loading and unloading, and transport vehicle vibrations. Airway assessment and care may also be suboptimal in the transport environment.

Indexed as

AdultAgedAged, 80 and overalpha-AmylasesBiomarkersFemaleHumansIntubation, IntratrachealLength of StayMaleMiddle AgedPepsin AProspective StudiesRespiratory AspirationRisk FactorsSingle-Blind Methodalpha-AmylasesBiomarkersPepsin A

Identifiers

PMID32869069
PMCPMC8344364
OpenAlexW3081876645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.