Evidence map›Paper›PMID 32868903›Full record

ArticleNature cell biology2020

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture.

Michelle Riegman, Liran Sagie, Chen Galed, Tom Levin, Noah Steinberg, Scott J Dixon, Ulrich Wiesner, Michelle S Bradbury, Philipp Niethammer, Assaf Zaritsky and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers.

0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

272 citing papers in PubMed, 450 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Ferroptosis in kidney disease.Nature reviews. Nephrology · 2026
    Review
  6. The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.Chembiochem : a European journal of chemical biology · 2026
    Review
  11. Article
  12. Review
  13. Caveolae mechanics in cellular functions and disease.Nature reviews. Molecular cell biology · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

212 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Michelle RiegmanLouis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7381-015X
Liran SagieDepartment of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Chen GaledDepartment of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID http://orcid.org/0000-0003-3186-0428
Tom LevinDepartment of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID http://orcid.org/0000-0002-0369-1711
Noah SteinbergCell Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.ORCID http://orcid.org/0000-0003-1337-1479
Scott J DixonDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6230-8199
Ulrich WiesnerDepartment of Materials Science & Engineering, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-6934-3755
Michelle S BradburyLouis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3147-4391
Philipp NiethammerLouis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4175-4012
Assaf ZaritskyDepartment of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel. assafza@bgu.ac.il.ORCID http://orcid.org/0000-0002-1477-5478
Michael OverholtzerLouis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. overhom1@mskcc.org.ORCID http://orcid.org/0000-0003-3007-4986
Ben-Gurion University of the Negev · ILMemorial Sloan Kettering Cancer Center · USCornell University · USKettering University · USStanford University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
The role of entosis in human cancersR01CA154649 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI OVERHOLTZER, MICHAEL H. · 2011 to 2020
$3.9M
Characterizing the Regulation of FerroptosisR01GM122923 · NIGMS · STANFORD UNIVERSITY · PI Scott Dixon · 2017 to 2026
$3.4M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA154649NIGMS NIH HHS R01 GM122923
6 · The paper itself

Abstract

Ferroptosis is a regulated form of necrotic cell death that is caused by the accumulation of oxidized phospholipids, leading to membrane damage and cell lysis

Indexed as

Cell DeathCell Line, TumorFerroptosisHeLa CellsHumansIronMCF-7 CellsNecrosisOsmosisPhospholipid Hydroperoxide Glutathione PeroxidaseU937 CellsIronPhospholipid Hydroperoxide Glutathione Peroxidase

Identifiers

PMID32868903
PMCPMC7644276
OpenAlexW3082740036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.