ArticleNature communications2020
Plasticity of muscle synergies through fractionation and merging during development and training of human runners.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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Who cites it
79 citing papers in PubMed, 158 citations in OpenAlex.
- Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of squat load and velocity on neuromuscular control strategies.European journal of applied physiology · 2026Article
- Neuromuscular Activation Strategies of the Lower Limb During Maximal Sprinting in Youth Track and Field Athletes: Age-Related Differences and Implications for Talent Identification.Sports (Basel, Switzerland) · 2026Article
- High-Intensity Exercise Performance as a Complex Adaptive System: An Integrative Review.Muscles (Basel, Switzerland) · 2026Review
- Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness.eLife · 2026Article
- Limb-specific modulation of muscle synergies and segmental coordination during curved running.Experimental brain research · 2026Article
- Age-related differences in whole-body muscle synergies during overarm throwing in children.Scientific reports · 2026Article
- Influence of surgical intervention on pre- and post-surgery patient specific muscle synergies in children with cerebral palsy.Experimental brain research · 2026Article
- Signal-Dependent Planning Noise Reduces Task Interference by Assisting in the Formation of Stable Motor Primitives in a Neural Network Model of Muscle Coordination Learning.Neural computation · 2026Article
- Relationship between lower limb muscle coordination and knee flexion angle during the swing phase of gait in post-stroke individuals.Journal of neuroengineering and rehabilitation · 2026Article
- Estimating and interpreting how humans prioritize multiple movement goals during walking.Journal of neuroengineering and rehabilitation · 2026Article
- User preference in the personalized control of an ankle prosthesis: a case study.Journal of neuroengineering and rehabilitation · 2026Article
- A modular architecture for trial-by-trial learning of redundant muscle activity patterns in novel sensorimotor tasks.PLoS computational biology · 2026Article
- Adaptive alterations in muscle synergies during the recovery step compensate for perturbation-induced stability demands in older adults.BMC geriatrics · 2026Article
- Shifts in the timing of gait muscle synergies in older adults with reduced lower-limb motor function.Experimental brain research · 2026Article
- Locomotion engages context-dependent motor strategies for head stabilization in primates.Communications biology · 2026Article
- Leveraging neural drive to assess hand motor function in individuals with chronic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- The effect of post-activation potentiation on neuromuscular activation of smashing technique during the recovery period of meniscal injuries in elite badminton players: non-negative matrix factorization-based muscle and time-frequency coherence.Frontiers in physiology · 2026Article
- Muscle synergy characteristics during hands-and-knees crawling in children aged 4-6 years.PloS one · 2026Article
- The role of independent walking in the maturation of the spinal locomotor output in children with cerebral palsy.Frontiers in physiology · 2026Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex motor commands for human locomotion are generated through the combination of motor modules representable as muscle synergies. Recent data have argued that muscle synergies are inborn or determined early in life, but development of the neuro-musculoskeletal system and acquisition of new skills may demand fine-tuning or reshaping of the early synergies. We seek to understand how locomotor synergies change during development and training by studying the synergies for running in preschoolers and diverse adults from sedentary subjects to elite marathoners, totaling 63 subjects assessed over 100 sessions. During development, synergies are fractionated into units with fewer muscles. As adults train to run, specific synergies coalesce to become merged synergies. Presences of specific synergy-merging patterns correlate with enhanced or reduced running efficiency. Fractionation and merging of muscle synergies may be a mechanism for modifying early motor modules (Nature) to accommodate the changing limb biomechanics and influences from sensorimotor training (Nurture).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.