Evidence map›Paper›PMID 32868775›Full record

ArticleScientific reports2020

CXCR4

Flavia Garcia, Rafaela Mendonça, Lediana I Miguel, Venina M Dominical, Sara T O Saad, Fernando F Costa, Nicola Conran

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Sickle red blood cells directly activate neutrophils.British journal of haematology · 2024
    Article
  6. Review
  7. Sickle cell vaso-occlusion: The dialectic between red cells and white cells.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Flavia GarciaHematology Center, University of Campinas - UNICAMP, Rua Carlos Chagas 480, Cidade Universitária, Campinas, SP, 13083-878, Brazil.
Rafaela MendonçaHematology Center, University of Campinas - UNICAMP, Rua Carlos Chagas 480, Cidade Universitária, Campinas, SP, 13083-878, Brazil.
Lediana I MiguelHematology Center, University of Campinas - UNICAMP, Rua Carlos Chagas 480, Cidade Universitária, Campinas, SP, 13083-878, Brazil.
Venina M DominicalFlow Cytometry Core Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Sara T O SaadHematology Center, University of Campinas - UNICAMP, Rua Carlos Chagas 480, Cidade Universitária, Campinas, SP, 13083-878, Brazil.
Fernando F CostaHematology Center, University of Campinas - UNICAMP, Rua Carlos Chagas 480, Cidade Universitária, Campinas, SP, 13083-878, Brazil.
Nicola ConranHematology Center, University of Campinas - UNICAMP, Rua Carlos Chagas 480, Cidade Universitária, Campinas, SP, 13083-878, Brazil. conran@unicamp.br.
Universidade Estadual de Campinas (UNICAMP) · BRNational Heart Lung and Blood Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukocyte recruitment and heterocellular aggregate formation drive the inflammatory vaso-occlusive processes associated with sickle cell anemia (SCA). We characterized neutrophils in a population of patients with SCA and investigated whether platelet-derived molecules can induce phenotypic alterations in this cell type. Imaging flow cytometry analysis demonstrated that the frequency of circulating CXCR4

Indexed as

Neutrophil ActivationAnemia, Sickle CellCase-Control StudiesCell DifferentiationFemaleFlow CytometryHumansMaleNeutrophilsReceptors, CXCR4SerotoninCXCR4 protein, humanReceptors, CXCR4Serotonin

Identifiers

PMID32868775
PMCPMC7459317
OpenAlexW3082482291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.