ArticleMedicine and science in sports and exercise2021
Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging.
Article in Medicine and science in sports and exercise, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 71 citations in OpenAlex.
- Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.Nature aging · 2025Trial
- Tiredness after work associates with less leisure-time physical activity.Scientific reports · 2024Trial
- Associations of weekly working hours with biological aging and all-cause and cardiovascular mortality: the role of lifestyle.Journal of occupational medicine and toxicology (London, England) · 2026Article
- The impact of different intensities of physical activity on aging: A Mendelian randomization study.Medicine · 2026Article
- Lifestyle change accelerates epigenetic ageing in King penguins.Nature communications · 2026Article
- Review
- Active longevity and aging: dissecting the impacts of physical and sedentary behaviors on longevity and age acceleration.GeroScience · 2025Observational
- Genetic and environmental contributions to epigenetic aging across adolescence and young adulthood.Clinical epigenetics · 2025Article
- Relationship between physical activity and DNA methylation-predicted epigenetic clocks.npj aging · 2025Article
- Physical activity and DNA methylation-based markers of ageing in 6208 middle-aged and older Australians: cross-sectional and longitudinal analyses.GeroScience · 2025Article
- Article
- Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study.Aging cell · 2025Article
- No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study.Brain, behavior, and immunity · 2025Article
- The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality - a prospective twin study.European journal of epidemiology · 2025Article
- Influence of physical activity on the epigenetic clock: evidence from a Japanese cross-sectional study.Clinical epigenetics · 2024Article
- Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality: Findings from the Finnish Twin Cohort.Medicine and science in sports and exercise · 2024Article
- Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks.BMC medicine · 2024Article
- Socioeconomic Status, Lifestyle, and DNA Methylation Age Among Racially and Ethnically Diverse Adults: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study.Aging cell · 2024Article
- Metabolic syndrome and epigenetic aging: a twin study.International journal of obesity (2005) · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
purposeGreater leisure-time physical activity (LTPA) associates with healthier lives, but knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA methylation (DNAm) patterns capture age-related changes in different tissues. We aimed to assess how LTPA and OPA are associated with three DNAm-based epigenetic age estimates, namely, DNAm age, PhenoAge, and GrimAge.
methodsThe participants were young adult (21-25 yr, n = 285) and older (55-74 yr, n = 235) twin pairs, including 16 pairs with documented long-term LTPA discordance. Genome-wide DNAm from blood samples was used to compute DNAm age, PhenoAge, and GrimAge Age acceleration (Acc), which describes the difference between chronological and epigenetic ages. Physical activity was assessed with sport, leisure-time, and work indices based on the Baecke Questionnaire. Genetic and environmental variance components of epigenetic age Acc were estimated by quantitative genetic modeling.
resultsEpigenetic age Acc was highly heritable in young adult and older twin pairs (~60%). Sport index was associated with slower and OPA with faster DNAm GrimAge Acc after adjusting the model for sex. Genetic factors and nonshared environmental factors in common with sport index explained 1.5%-2.7% and 1.9%-3.5%, respectively, of the variation in GrimAge Acc. The corresponding proportions considering OPA were 0.4%-1.8% and 0.7%-1.8%, respectively. However, these proportions were minor (<0.5%) after adjusting the model for smoking status.
conclusionsLTPA associates with slower and OPA with faster epigenetic aging. However, adjusting the models for smoking status, which may reflect the accumulation of unhealthy lifestyle habits, attenuated the associations.
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