ArticleProceedings of the National Academy of Sciences of the United States of America2020
Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in
Erratum issuedAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- A critical role forProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system.Frontiers in cellular and infection microbiology · 2025Review
- Pathogenicity and virulence ofVirulence · 2024Review
- Towards a Yersinia pestis lipid A recreated in an Escherichia coli scaffold genome.Access microbiology · 2024Article
- Structure Determination of Lipid A with Multiple Glycosylation Sites by Tandem MS of Lithium-Adducted Negative Ions.Journal of the American Society for Mass Spectrometry · 2023Article
- Heterogeneity of Lipopolysaccharide as Source of Variability in Bioassays and LPS-Binding Proteins as Remedy.International journal of molecular sciences · 2023Review
- Lipid A structural diversity among members of the genusFrontiers in microbiology · 2023Article
- Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation.Infection and immunity · 2022Article
- Lipid A Structural Determination from a Single Colony.Analytical chemistry · 2022Article
- Hyperproduction of PHA copolymers containing high fractions of 4-hydroxybutyrate (4HB) by outer membrane-defected Halomonas bluephagenesis grown in bioreactors.Microbial biotechnology · 2022Article
- RemodelingProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Deletion of Yersinia pestisJournal of bacteriology · 2021Article
- Lipopolysaccharide of theBiomolecules · 2021Review
- Mobile Colistin Resistance Enzyme MCR-3 Facilitates Bacterial Evasion of Host Phagocytosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Novel TLR4 adjuvant elicits protection against homologous and heterologous Influenza A infection.Vaccine · 2021Article
- Article
- Diversification of CD1 Molecules Shapes Lipid Antigen Selectivity.Molecular biology and evolution · 2021Article
- Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.The Journal of biological chemistry · 2020Review
- The Diverse Roles of the Global Transcriptional Regulator PhoP in the Lifecycle ofPathogens (Basel, Switzerland) · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Courtney E ChandlerDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201.ORCID 0000-0003-2076-3665
Erin M HarbertsDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201.ORCID 0000-0002-9440-5011
Mark R PelletierDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201.
Iyarit ThaipisuttikulDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700.
Jace W JonesDepartment of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201.ORCID 0000-0003-0460-0380
Adeline M HajjarDepartment of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195.ORCID 0000-0002-4838-8070
Jason W SahlDepartment of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011.
David R GoodlettDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201.ORCID 0000-0002-8045-8200
Aaron C PrideDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712.ORCID 0000-0001-7855-9208
David A RaskoInstitute for Genome Sciences, University of Maryland, Baltimore, MD 21201.
M Stephen TrentDepartment of Infectious Diseases, University of Georgia, Athens, GA 30602.ORCID 0000-0001-6134-1800
Russell E BishopDepartment of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8S4L8.
Robert K ErnstDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, MD 21201; rkernst@umaryland.edu.ORCID 0000-0001-5016-8694
Funding
Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FRASER, CLAIRE M., RASKO, DAVID A · 2014 to 2023
$36.5MThe Cell Envelope of the Multi-Drug Resistant Pathogen Acinetobacter baumanniiR01AI150098 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2020 to 2026
$3.9MDevelopment of a novel vaccine platform: Surface Antigen/Adjuvant Vaccine Engineering (SAAVE)R01AI129940 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2017 to 2021
$3.3MMolecular mechanisms required for the maintenance of the gram-negative outer membraneR01AI138576 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2018 to 2022
$2.0MProtection Against Gram-Negative Sepsis Conferred by Lipid A-Based Structural VariantsR01AI123820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2016 to 2019
$1.5MMS diagnostic bacterial identification libraryR01GM111066 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2014 to 2017
$1.2MCIHR MOP-125979NIAID NIH HHS R01 AI123820NIAID NIH HHS R01 AI129940NIAID NIH HHS R01 AI138576NIAID NIH HHS R01 AI150098NIAID NIH HHS U19 AI110820NIGMS NIH HHS R01 GM111066
Abstract
Immune evasion through membrane remodeling is a hallmark of
Indexed as
AcyltransferasesAnimalsBiological EvolutionCell LineCell Line, TumorHEK293 CellsHumansImmune EvasionImmunity, InnateLeukocytes, MononuclearLipid ALipopolysaccharidesMiceMice, Inbred BALB CMice, Inbred C57BLPolymorphism, Single NucleotideAcyltransferasesLipid ALipopolysaccharidesevolutionimmune evasionlipid ApathogenesisYersinia
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.