Evidence map›Paper›PMID 32868418›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Relationship of estrogen synthesis capacity in the brain with obesity and self-control in men and women.

Anat Biegon, Nelly Alia-Klein, David L Alexoff, Joanna S Fowler, Sung Won Kim, Jean Logan, Deborah Pareto, Rebecca Preston-Campbell, Gene-Jack Wang, Tom Hildebrandt

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Brain-derived estrogen and neural function.Neuroscience and biobehavioral reviews · 2022
    Review
  7. Review
  8. Review
  9. Aromatase in the Human Brain.Androgens: clinical research and therapeutics · 2021
    Review
  10. Review
  11. Unravelling the role of oestrogen in feeding control.Nature reviews. Endocrinology · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Anat BiegonDepartment of Radiology & Neurology, Stony Brook University School of Medicine, Stony Brook, NY 11794; anat.biegon@stonybrookmedicine.edu fowler@bnl.gov.ORCID 0000-0002-2696-5949
Nelly Alia-KleinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
David L AlexoffFiveeleven Pharma, Philadelphia, PA 19104.
Joanna S FowlerDepartment of Chemistry, Brookhaven National Laboratory, Upton, NY 11973; anat.biegon@stonybrookmedicine.edu fowler@bnl.gov.
Sung Won KimLaboratory of Neuroimaging, National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD 20892.
Jean LoganDepartment of Radiology, New York University Langone Medical Center, New York, NY 10016.
Deborah ParetoMagnetic Resonance Unit, Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
Rebecca Preston-CampbellMissouri Institute of Mental Health, St. Louis, MO 63134.
Gene-Jack WangLaboratory of Neuroimaging, National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD 20892.ORCID 0000-0002-5017-9905
Tom HildebrandtDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Icahn School of Medicine at Mount Sinai · USNational Institute on Alcohol Abuse and Alcoholism · USBrookhaven National Laboratory · USMissouri Institute of Mental Health · USNYU Langone Health · USStony Brook University · USVall d'Hebron Hospital Universitari · ES

Funding

[11C]vorozole as a PET tracer for in vivo studies of human aromataseR21EB012707 · NIBIB · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI BIEGON, ANAT · 2011 to 2012
$577k
NIBIB NIH HHS R21 EB012707
6 · The paper itself

Abstract

Gonadal hormones are linked to mechanisms that govern appetitive behavior and its suppression. Estrogens are synthesized from androgens by the enzyme aromatase, highly expressed in the ovaries of reproductive-aged women and in the brains of men and women of all ages. We measured aromatase availability in the amygdala using positron emission tomography (PET) with the aromatase inhibitor [

Indexed as

AdultAgedAmygdalaAndrogensAppetiteAromataseAromatase InhibitorsBody Mass IndexBrainEstrogensFemaleHumansLipogenesisMaleMiddle AgedObesityAndrogensAromataseAromatase InhibitorsEstrogensamygdalaaromataseestrogenobesityPET imaging

Identifiers

PMID32868418
PMCPMC7502739
OpenAlexW3081645983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.