Evidence map›Paper›PMID 32868373›Full record

ArticleMolecular & cellular proteomics : MCP2020

The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.

Teresa M Buck, Xuemei Zeng, Pamela S Cantrell, Richard T Cattley, Zikri Hasanbasri, Megan E Yates, Diep Nguyen, Nathan A Yates, Jeffrey L Brodsky

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Teresa M BuckDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Xuemei ZengBiomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA.
Pamela S CantrellBiomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA.
Richard T CattleyBiomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA.
Zikri HasanbasriDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Megan E YatesDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Diep NguyenDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nathan A YatesBiomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
Jeffrey L BrodskyDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: jbrodsky@pitt.edu.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2008 to 2022
$13.4M
Modulating Hsp70-dependent proteostasis in Alzheimer's DiseaseR35GM131732 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JEFFREY L. BRODSKY · 2019 to 2026
$3.4M
Role of GRP170 in ENaC Biogenesis and Renal PhysiologyR01DK117126 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCK, TERESA M · 2019 to 2023
$1.7M
Investigating the role of GRP170 in ENaC biogenesisR03DK109024 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCK, TERESA M · 2016 to 2017
$154k
NCI NIH HHS P30 CA047904NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK117126NIDDK NIH HHS R03 DK109024NIGMS NIH HHS R35 GM131732
6 · The paper itself

Abstract

Studies in the yeast

Indexed as

ATP-Binding Cassette TransportersChromatography, LiquidEndoplasmic ReticulumEndoplasmic Reticulum-Associated DegradationErgosterolLeupeptinsMixed Function OxygenasesProteasome Endopeptidase ComplexProteasome InhibitorsProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTandem Mass SpectrometryUbiquitinUbiquitinationATP-Binding Cassette Transportersbenzyloxycarbonylleucyl-leucyl-leucine aldehydeERG25 protein, S cerevisiaeErgosterolLeupeptinsMixed Function OxygenasesPDR5 protein, S cerevisiaeProteasome Endopeptidase ComplexProteasome InhibitorsSaccharomyces cerevisiae ProteinsUbiquitinERADmass spectrometryproteasomeprotein complex analysisProtein degradationprotein foldingubiquitinyeast

Identifiers

PMID32868373
PMCPMC7664122
OpenAlexW3082078584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.