Evidence map›Paper›PMID 32868344›Full record

ArticleInfection and immunity2020

Cigarette Smoke Exposure Promotes Virulence of Pseudomonas aeruginosa and Induces Resistance to Neutrophil Killing.

Jason Chien, John H Hwang, Sedtavut Nilaad, Jorge A Masso-Silva, Sae Jeong Ahn, Elisa K McEachern, Alexander Moshensky, Min-Kwang Byun, Laura E Crotty Alexander

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Association of Chronic Rhinosinusitis andChronic obstructive pulmonary diseases (Miami, Fla.) · 2026
    Article
  3. Cigarette smoke modulates virulence-related properties and host immune responses inFrontiers in cellular and infection microbiology · 2026
    Article
  4. Review
  5. Tobacco smoke exposure is associated with diminished longitudinal benefit of elexacaftor/tezacaftor/ivacaftor in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Smoking-induced microbial dysbiosis in health and disease.Clinical science (London, England : 1979) · 2022
    Review
  14. Transcriptional Response ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jason Chien *Pulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
John H Hwang *Pulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
Sedtavut Nilaad *Pulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
Jorge A Masso-Silva *Pulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
Sae Jeong AhnPulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
Elisa K McEachernPulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
Alexander MoshenskyPulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
Min-Kwang ByunPulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA.
Laura E Crotty AlexanderPulmonary and Critical Care Section, VA San Diego Healthcare System, La Jolla, California, USA lca@ucsd.edu.ORCID 0000-0002-5091-2660
University of California System · USYonsei University · KR

Funding

Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory PathwaysR01HL137052 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CROTTY ALEXANDER, LAURA ELISE · 2017 to 2021
$2.3M
Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways diseaseI01BX004767 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CROTTY ALEXANDER, LAURA ELISE · 2020 to 2023
–
Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthmaIK2BX001313 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CROTTY ALEXANDER, LAURA ELISE · 2011 to 2015
–
BLRD VA I01 BX004767BLRD VA IK2 BX001313NHLBI NIH HHS R01 HL137052
6 · The paper itself

Abstract

It is widely known that cigarette smoke damages host defenses and increases susceptibility to bacterial infections.

Indexed as

AnimalsGene Expression Regulation, BacterialHumansMiceNeutrophilsPseudomonas aeruginosaPseudomonas InfectionsSmokeTobacco ProductsVirulenceSmokebacterial virulencebiofilmcigarette smokeneutrophiloxidative burstpneumoniaPseudomonas aeruginosa

Identifiers

PMID32868344
PMCPMC7573448
OpenAlexW3082481826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.