Evidence map›Paper›PMID 32868341›Full record

ArticleInfection and immunity2020

Effects of Immunomodulatory Drug Fingolimod (FTY720) on

Zengzi Zhou, Lingxiang Xie, Luying Wang, Min Xue, Dabao Xu, Guangming Zhong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. mBio · 2025
    Article
  4. FTY720 Reduces the Biomass of Biofilms inAntibiotics (Basel, Switzerland) · 2024
    Article
  5. Article
  6. ACS infectious diseases · 2022
    Article
  7. Gastrointestinal Chlamydia-Induced CD8Infection and immunity · 2021
    Article
  8. Infection and immunity · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zengzi ZhouThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lingxiang XieDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Luying WangThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Min XueThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Dabao XuThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China dabaoxu@yahoo.com Zhongg@UTHSCSA.EDU.
Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA dabaoxu@yahoo.com Zhongg@UTHSCSA.EDU.ORCID 0000-0001-7053-5009
Central South University · CNThe University of Texas Health Science Center at San Antonio · US

Funding

MECHANISMS OF CHLAMYDIAL EVASION OF IMMUNE RECOGNATIONR01AI047997 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2000 to 2021
$6.9M
Chlamydial plasmid-dependent pathogenesisR01AI121989 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2016 to 2019
$1.9M
Genital Chlamydia spreading to the gastrointestinal tract promotes chlamydial pathogenicity in the upper genital tractR21AI151724 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2020 to 2021
$416k
NIAID NIH HHS R01 AI047997NIAID NIH HHS R01 AI121989NIAID NIH HHS R21 AI151724
6 · The paper itself

Abstract

Fingolimod (FTY720), an FDA-approved immunomodulatory drug for treating multiple sclerosis, is an agonist of sphingosine-1-phosphate receptor (S1PR), which has been used as a research tool for inhibiting immune cell trafficking. FTY720 was recently reported to inhibit

Indexed as

AnimalsChlamydia InfectionsChlamydia muridarumColonFemaleFingolimod HydrochlorideMiceMice, Inbred C57BLMice, Inbred CBASphingosine 1 Phosphate Receptor ModulatorsFingolimod HydrochlorideSphingosine 1 Phosphate Receptor ModulatorschlamydiadisseminationfingolimodFTY720hydrosalpinx

Identifiers

PMID32868341
PMCPMC7573440
OpenAlexW3082441635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.