Evidence map›Paper›PMID 32868318›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

Diet and Risk of Myeloproliferative Neoplasms in Older Individuals from the NIH-AARP Cohort.

Nikolai A Podoltsev, Xiaoyi Wang, Rong Wang, Jonathan N Hofmann, Linda M Liao, Amer M Zeidan, Ruben A Mesa, Xiaomei Ma

Open access · bronzeAbstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nikolai A PodoltsevDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0002-3657-778X
Xiaoyi WangDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Rong WangDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Jonathan N HofmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Amer M ZeidanDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, Connecticut.
Ruben A MesaMays Cancer Center, University of Texas, San Antonio, Texas.
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut. xiaomei.ma@yale.edu.
Yale University · USNational Cancer Institute · USTexas Oncology · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
NCI NIH HHS P30 CA054174
6 · The paper itself

Abstract

backgroundThe etiology of myeloproliferative neoplasms (MPN) is obscure, and no previous studies have evaluated the role of diet.

methodsIn the NIH-AARP Diet and Health Study, a prospective cohort of 463,049 participants ages 50 to 71 years at baseline (1995-1996), we identified 490 MPN cases after a median follow-up of 15.5 years, including 190 with polycythemia vera (PV) and 146 with essential thrombocythemia (ET). We examined possible associations between various dietary factors and the risk of MPN as a group, as well as PV and ET, using multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) and adjust for potential confounding variables.

resultsAn increased risk was observed between fruit consumption and the risk of MPN overall (third tertile vs. first tertile, HR = 1.32; 95% CI, 1.04-1.67;

conclusionsThe intake of fat and protein did not appear to influence PV risk-neither did meat or vegetable consumption. None of the dietary factors studied was associated with the risk of ET. The role of sugar intake in the etiology of PV in older individuals warrants further investigation. IMPACT: Our results indicate that high sugar intake is associated with an increased risk of polycythemia vera.

Indexed as

AgedCohort StudiesDietFemaleHumansMaleMiddle AgedMyeloproliferative DisordersNational Institutes of Health (U.S.)United States

Identifiers

PMID32868318
PMCPMC8895351
OpenAlexW3081822006

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.