Evidence map›Paper›PMID 32868298›Full record

ArticleMolecular cancer research : MCR2020

Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype.

Christopher J Hanley, Elodie Henriet, Orit Katarina Sirka, Gareth J Thomas, Andrew J Ewald

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Research progress on the expression characteristics, biological functions, and therapeutic potential of NOX4 in malignant tumors: a functional perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Collective migration modes in development, tissue repair and cancer.Nature reviews. Molecular cell biology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Leader Cells: Invade and Evade-The Frontline of Cancer Progression.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Christopher J Hanley *School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-3816-7220
Elodie Henriet *Departments of Cell Biology, Oncology, and Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Orit Katarina SirkaDepartments of Cell Biology, Oncology, and Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gareth J Thomas *School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-3832-7335
Andrew J Ewald *Departments of Cell Biology, Oncology, and Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland. andrew.ewald@jhmi.edu.ORCID 0000-0002-1964-0740
Johns Hopkins University · USUniversity of Southampton · GB

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2016 to 2020
$9.9M
Pathway Discovery and Target Validation for Outgrowth of Breast Cancer MetastasesU01CA217846 · NCI · JOHNS HOPKINS UNIVERSITY · PI BADER, JOEL S., EWALD, ANDREW JOSEF · 2017 to 2021
$4.8M
Integrating bioinformatics into multiscale models for hepatocellular carcinomaU01CA212007 · NCI · JOHNS HOPKINS UNIVERSITY · PI EWALD, ANDREW JOSEF, FERTIG, ELANA · 2018 to 2022
$3.2M
Cancer Research UK 24808Cancer Research UK 27989NCI NIH HHS P30 CA006973NCI NIH HHS U01 CA212007NCI NIH HHS U01 CA217846NCI NIH HHS U54 CA210173
6 · The paper itself

Abstract

Collective invasion can be led by breast cancer cells expressing basal epithelial markers, typified by keratin-14 (KRT14). We analyzed gene expression data from The Cancer Genome Atlas and demonstrated a significant correlation between a KRT14

Indexed as

AnimalsBreast NeoplasmsComputational BiologyFemaleHumansMiceNeoplasm InvasivenessPhenotypeStromal Cells

Identifiers

PMID32868298
PMCPMC7642004
OpenAlexW3082220472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.