Evidence map›Paper›PMID 32868296›Full record

ArticleThe Journal of biological chemistry2020

Capping protein is dispensable for polarized actin network growth and actin-based motility.

Majdouline Abou-Ghali, Remy Kusters, Sarah Körber, John Manzi, Jan Faix, Cécile Sykes, Julie Plastino

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Majdouline Abou-GhaliLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, Paris, France; Sorbonne Université, Paris, France.
Remy KustersCentre de Recherche Interdisciplinaire, Université de Paris, INSERM U1284, Paris, France.
Sarah KörberInstitute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany.
John ManziLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, Paris, France; Sorbonne Université, Paris, France.
Jan FaixInstitute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany.
Cécile SykesLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, Paris, France; Sorbonne Université, Paris, France.
Julie PlastinoLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, Paris, France; Sorbonne Université, Paris, France. Electronic address: julie.plastino@curie.fr.
Centre National de la Recherche Scientifique · FRMedizinische Hochschule Hannover · DEInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterodimeric capping protein (CP) binds the rapidly growing barbed ends of actin filaments and prevents the addition (or loss) of subunits. Capping activity is generally considered to be essential for actin-based motility induced by Arp2/3 complex nucleation. By stopping barbed end growth, CP favors nucleation of daughter filaments at the functionalized surface where the Arp2/3 complex is activated, thus creating polarized network growth, which is necessary for movement. However, here using an

Indexed as

Actin Capping ProteinsActin CytoskeletonActin-Related Protein 2-3 ComplexActinsAnimalsDNA-Binding ProteinsForminsMicePolymerizationRabbitsSwineActin Capping ProteinsActin-Related Protein 2-3 ComplexActinsDNA-Binding ProteinsENA-VASP proteinsForminsactinactin polymerizationArp2/3 complexbiophysicscapping proteincell motilitycytoskeletonEna/VASP proteinsin vitro systems

Identifiers

PMID32868296
PMCPMC7650241
OpenAlexW3081823320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.