ArticleThorax2020
Serum free testosterone and asthma, asthma hospitalisations and lung function in British adults.
Article in Thorax, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Impact of Sex on Prediction of Asthma Attacks by Clinical Risk Factors and Type 2 Biomarkers.Chest · 2026Pooled it
- Randomized study of the effects of testosterone administration on severity of asthma in horses.Journal of veterinary internal medicine · 2026Article
- Urinary sodium, table salt use and incidence of late-onset asthma in females and males: evidence from a large prospective cohort.ERJ open research · 2026Article
- Transcriptome-wide association study of sex effects identifies sex-specific nasal epithelial gene expression profiles for total IgE.The Journal of allergy and clinical immunology · 2026Article
- Androgens are a Key Factor Affecting Immune Related Diseases.The world journal of men's health · 2026Review
- A pilot study reveals plasma metabolomic and lipidomic signatures of mustard lung disease.Scientific reports · 2026Article
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- The testosterone paradox in asthma.Frontiers in allergy · 2026Review
- Increased platelet counts are associated with female sex and asthma severity.The journal of allergy and clinical immunology. Global · 2025Article
- Aeroallergen IgE-Reactivity Patterns and Respiratory Allergy in Children and Adults: A Retrospective Study in 1711 Patients from the Central Poland Urban Area.Medicina (Kaunas, Lithuania) · 2025Article
- Association between orchiectomy and asthma: Insights from 2 population-based cohorts.The journal of allergy and clinical immunology. Global · 2025Article
- Association between sleep duration and lung function among U.S. adults.BMC public health · 2024Article
- Gender-specific association between a lipid composite index and asthma among US adults: insights from a population-based study.Lipids in health and disease · 2024Article
- Sex Hormones and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study and Mendelian Randomization Analysis.International journal of chronic obstructive pulmonary disease · 2024Article
- Serum α-Klotho level, lung function, airflow obstruction and inflammatory markers in US adults.ERJ open research · 2023Article
- Adverse Events during Adulthood, Child Maltreatment, and Asthma among British Adults in the UK Biobank.Annals of the American Thoracic Society · 2023Article
- Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA.BMJ open respiratory research · 2023Observational
- A Between-Sex Comparison of the Genomic Architecture of Asthma.American journal of respiratory cell and molecular biology · 2023Article
- The association of asthma duration with body mass index and Weight-Adjusted-Waist index in a nationwide study of the U.S. adults.European journal of medical research · 2023Article
- The Influence of Sex Hormones and X Chromosome in Immune Responses.Current topics in microbiology and immunology · 2023Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe examined the relation between serum-free testosterone and asthma, wheeze, asthma hospitalisations and lung function in older adults.
designCross-sectional study.
settingUK.
participants256 419 adults aged 40 to 69 years, recruited from 2006 to 2010.
main outcome measuresMultivariable logistic or linear regression was used for the analysis of free testosterone and physician-diagnosed asthma, current wheeze, asthma hospitalisations and lung function measures, which was adjusted for serum estradiol, smoking status and other covariates.
resultsFree testosterone levels above the lowest quartile (Q1) were significantly associated with lower odds of asthma in both women (adjusted OR (aOR) for Q4 (the highest quartile) versus Q1=0.67, 95% CI=0.64 to 0.71) and men (aOR for Q4 versus Q1=0.87, 95% CI=0.82 to 0.91). Among subjects with asthma, free testosterone levels above Q1 were significantly associated with lower odds of current wheeze in women (aOR range=0.78 to 0.87), and free testosterone levels in Q4 were associated with lower odds of current wheeze in men (aOR for Q4 versus Q1=0.86, 95% CI=0.77 to 0.95). Among women with asthma, free testosterone levels in Q4 were also associated with lower odds of ≥1 asthma hospitalisation. Among men, free testosterone was positively associated with FEV
conclusionIn a large study of British adults, elevated free testosterone levels are associated with lower odds of asthma and current wheeze in women and men, lower odds of asthma hospitalisations in women, and higher FEV
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.