Evidence map›Paper›PMID 32867847›Full record

ReviewTranslational neurodegeneration2020

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease.

Lingling Lv, Xuling Tan, Xinke Peng, Rongrong Bai, Qile Xiao, Ting Zou, Jieqiong Tan, Hainan Zhang, Chunyu Wang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational neurodegeneration, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Neuroprotection of engineeredJournal of Zhejiang University. Science. B · 2026
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  19. Does vitamin D protect or treat Parkinson's disease? A narrative review.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lingling LvDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Xuling TanDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Xinke PengDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Rongrong BaiDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Qile XiaoDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Ting ZouDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Jieqiong TanCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, 410078, China.
Hainan ZhangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Chunyu WangDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. wangchunyu@csu.edu.cn.ORCID 0000-0003-1629-0885
Central South University · CN

Funding

National Natural Science Foundation of China 81971201Natural Science Foundation of Hunan Province 2019JJ40450
6 · The paper itself

Abstract

In recent years, many studies have investigated the correlations between Parkinson's disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor (VDR) gene polymorphisms from PubMed, Web of Science, Cochrane Library, and Embase databases. We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity. Furthermore, higher vitamin D concentrations are linked to better cognitive function and mood in PD patients. Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent, but the FokI (C/T) polymorphism is significantly linked with PD. The occurrence of FokI (C/T) gene polymorphism may influence the risk, severity, and cognitive ability of PD patients, while also possibly influencing the effect of Vitamin D

Indexed as

Dietary SupplementsCase-Control StudiesGenetic Predisposition to DiseaseHumansParkinson DiseasePolymorphism, Single NucleotideProspective StudiesReceptors, CalcitriolVitamin DVitamin D DeficiencyReceptors, CalcitriolVDR protein, humanVitamin DDopaminergic neurotransmissionNeuroprotectiveParkinson’s diseaseVDR gene polymorphismsVitamin DVitamin D3 supplementation

Identifiers

PMID32867847
PMCPMC7460797
OpenAlexW3081920050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.