ArticleJournal of nanobiotechnology2020
The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles.
Article in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Bone matrix-inspired whitlockite porous ceramic with effects of autophagy activation contributes to bone regeneration.Bioactive materials · 2026Article
- Nano-dicalcium silicate promotes angiogenesis via enhancing endothelial cell proliferation, migration and tube formation.Journal of materials science. Materials in medicine · 2026Article
- CYB5A promotes osteogenic differentiation of MC3T3-E1 cells through autophagy mediated by the AKT/mTOR/ULK1 signaling pathway.Scientific reports · 2025Article
- Calcium silicate induces mitophagy-mediated metabolic shifts toward oxidative phosphorylation in BMSCs to facilitate osteogenesis and bone regeneration.Regenerative biomaterials · 2025Article
- The Role of Mitochondrial Homeostasis in Mesenchymal Stem Cell Therapy-Potential Implications in the Treatment of Osteogenesis Imperfecta.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- Bioactive ceramic-based materials: beneficial properties and potential applications in dental repair and regeneration.Regenerative medicine · 2024Review
- The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives.Biomimetics (Basel, Switzerland) · 2024Review
- Insights and implications of sexual dimorphism in osteoporosis.Bone research · 2024Review
- Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration.Cell communication and signaling : CCS · 2024Review
- AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.Cell proliferation · 2024Article
- Research advances of nanomaterials for the acceleration of fracture healing.Bioactive materials · 2024Review
- mTOR signalling pathway in stem cell bioactivities and angiogenesis potential.Cell proliferation · 2023Review
- Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications.Pharmaceutics · 2023Review
- Article
- Review
- Osteogenic effects of rapamycin on bone marrow mesenchymal stem cells via inducing autophagy.Journal of orthopaedic surgery and research · 2023Article
- High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma.Cancer cell international · 2022Article
- Silicified collagen scaffold induces semaphorin 3A secretion by sensory nerves to improveBioactive materials · 2022Article
- Dicalcium silicate-induced mitochondrial dysfunction and autophagy-mediated macrophagic inflammation promotes osteogenic differentiation of BMSCs.Regenerative biomaterials · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A novel bioactive inorganic material containing silicon, calcium and oxygen, calcium silicate (Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.