Evidence map›Paper›PMID 32867470›Full record

ReviewChemical reviews2020

Biomaterials for Bioprinting Microvasculature.

Ryan W Barrs, Jia Jia, Sophia E Silver, Michael Yost, Ying Mei

Abstract readReview
In one paragraph

Review in Chemical reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan W BarrsBioengineering Department, Clemson University, Clemson, South Carolina 29634, United States.
Jia JiaBioengineering Department, Clemson University, Clemson, South Carolina 29634, United States.
Sophia E SilverBioengineering Department, Clemson University, Clemson, South Carolina 29634, United States.
Michael YostDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
Ying MeiBioengineering Department, Clemson University, Clemson, South Carolina 29634, United States.ORCID 0000-0002-8508-4076

Funding

Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MARKWALD, ROGER R, VYAVAHARE, NAREN R · 2012 to 2018
$14.9M
Nanowired human cardiac spheroids for heart repairR01HL133308 · NHLBI · CLEMSON UNIVERSITY · PI MEI, YING · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL133308NIGMS NIH HHS P20 GM103444
6 · The paper itself

Abstract

Microvasculature functions at the tissue and cell level, regulating local mass exchange of oxygen and nutrient-rich blood. While there has been considerable success in the biofabrication of large- and small-vessel replacements, functional microvasculature has been particularly challenging to engineer due to its size and complexity. Recently, three-dimensional bioprinting has expanded the possibilities of fabricating sophisticated microvascular systems by enabling precise spatiotemporal placement of cells and biomaterials based on computer-aided design. However, there are still significant challenges facing the development of printable biomaterials that promote robust formation and controlled 3D organization of microvascular networks. This review provides a thorough examination and critical evaluation of contemporary biomaterials and their specific roles in bioprinting microvasculature. We first provide an overview of bioprinting methods and techniques that enable the fabrication of microvessels. We then offer an in-depth critical analysis on the use of hydrogel bioinks for printing microvascularized constructs within the framework of current bioprinting modalities. We end with a review of recent applications of bioprinted microvasculature for disease modeling, drug testing, and tissue engineering, and conclude with an outlook on the challenges facing the evolution of biomaterials design for bioprinting microvasculature with physiological complexity.

Indexed as

BioprintingMicrovesselsPrinting, Three-DimensionalTissue EngineeringBiocompatible MaterialsHumansBiocompatible Materials

Identifiers

PMID32867470
PMCPMC7810139

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.