Evidence map›Paper›PMID 32867391›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model.

Zbynek Novy, Volodymyr Lobaz, Martin Vlk, Jan Kozempel, Petr Stepanek, Miroslav Popper, Jana Vrbkova, Marian Hajduch, Martin Hruby, Milos Petrik

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zbynek NovyInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
Volodymyr LobazInstitute of Macromolecular Chemistry AS CR, Heyrovskeho namesti 1888/2, 162 06 Prague 6, Czech Republic.ORCID 0000-0003-0479-2837
Martin VlkDepartment of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Brehova 7, 115 19 Prague 1, Czech Republic.ORCID 0000-0003-1044-1910
Jan KozempelDepartment of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Brehova 7, 115 19 Prague 1, Czech Republic.ORCID 0000-0002-6315-9225
Petr StepanekInstitute of Macromolecular Chemistry AS CR, Heyrovskeho namesti 1888/2, 162 06 Prague 6, Czech Republic.
Miroslav PopperInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
Jana VrbkovaInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
Marian HajduchInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
Martin HrubyInstitute of Macromolecular Chemistry AS CR, Heyrovskeho namesti 1888/2, 162 06 Prague 6, Czech Republic.
Milos PetrikInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.ORCID 0000-0003-1334-5916
Institute of Molecular and Translational Medicine · CZCzech Academy of Sciences, Institute of Macromolecular Chemistry · CZCzech Technical University in Prague · CZ

Funding

Ministerstvo Zdravotnictví Ceské Republiky 16-30544AMinisterstvo Zdravotnictví Ceské Republiky NU20-08-00095Ministry of Education, Youth and Sports of the Czech Republic EATRIS-CZ LM2015064 ERIC
6 · The paper itself

Abstract

Nanoparticles (NPs) represent an emerging platform for diagnosis and treatment of various diseases such as cancer, where they can take advantage of enhanced permeability and retention (EPR) effect for solid tumor accumulation. To improve their colloidal stability, prolong their blood circulation time and avoid premature entrapment into reticuloendothelial system, coating with hydrophilic biocompatible polymers is often essential. Most studies, however, employ just one type of coating polymer. The main purpose of this study is to head-to-head compare biological behavior of three leading polymers commonly used as "stealth" coating materials for biocompatibilization of NPs poly(ethylene oxide), poly(2-ethyl-2-oxazoline) and poly[

Indexed as

animal modelhydroxyapatitenanoparticlespoly(2-ethyl-2-oxazoline)poly(ethylene oxide)poly[N-(2-hydroxypropyl)methacrylamide]solid tumor

Identifiers

PMID32867391
PMCPMC7558523
OpenAlexW3080174150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.