Evidence map›Paper›PMID 32867324›Full record

ArticleMolecules (Basel, Switzerland)2020

New Hybrids of 4-Amino-2,3-polymethylene-quinoline and

Galina F Makhaeva, Nadezhda V Kovaleva, Natalia P Boltneva, Sofya V Lushchekina, Tatiana Yu Astakhova, Elena V Rudakova, Alexey N Proshin, Igor V Serkov, Eugene V Radchenko, Vladimir A Palyulin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Galina F MakhaevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-8136-6906
Nadezhda V KovalevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Natalia P BoltnevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-7171-8832
Sofya V LushchekinaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-6922-020X
Tatiana Yu AstakhovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.
Elena V RudakovaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-4600-7799
Alexey N ProshinInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Igor V SerkovInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Eugene V RadchenkoInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-2091-7022
Vladimir A PalyulinInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0001-8792-8386
Sergey O BachurinInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0003-3637-818X
Rudy J RichardsonDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Institute of Physiologically Active Compounds · RUInstitute of Biochemical Physics NM Emanuel · RULomonosov Moscow State University · RUUniversity of Michigan · US

Funding

IPAC RAS State Targets Project 0090-2019-0005Russian Foundation for Basic Research 19-53-26016_a
6 · The paper itself

Abstract

New hybrid compounds of 4-amino-2,3-polymethylene-quinoline containing different sizes of the aliphatic ring and linked to

Indexed as

AntioxidantsCholinesterase InhibitorsDrug DiscoveryQuinolinesSulfonamidesAlzheimer DiseaseDrug InteractionsHumansModels, MolecularStructure-Activity RelationshipAntioxidantsCholinesterase InhibitorsQuinolinesSulfonamides4-amino-2,3-polymethylene-quinolineacetylcholinesterase (AChE)ADMETAlzheimer’s disease (AD)butyrylcholinesterase (BChE)molecular dockingp-tolylsulfonamide

Identifiers

PMID32867324
PMCPMC7504258
OpenAlexW3080321652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.