ArticleMetabolites2020
Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics.
Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Association of maternal blood metabolomics and gestational diabetes mellitus risk: a systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2025Pooled it
- Metabolomics reveals early pregnancy serum metabolic changes and predictive biomarkers in gestational diabetes mellitus.Nutrition & metabolism · 2026Article
- Gestational age and models for predicting gestational diabetes mellitus.Metabolomics : Official journal of the Metabolomic Society · 2025Observational
- Article
- Correlation between newborn weight and serum BCAAs in pregnant women with diabetes.Nutrition & diabetes · 2024Article
- The role of lipid dysregulation in gestational diabetes mellitus: Early prediction and postpartum prognosis.Journal of diabetes investigation · 2024Review
- Metabolic dynamics and prediction of sFGR and adverse fetal outcomes: a prospective longitudinal cohort study.BMC medicine · 2023Article
- Metabolomics can provide new insights into perinatal nutrition.Acta paediatrica (Oslo, Norway : 1992) · 2023Review
- Predictive Gestational Diabetes Biomarkers With Sustained Alterations Throughout Pregnancy.Journal of the Endocrine Society · 2022Review
- Longitudinal associations of pre-pregnancy BMI and gestational weight gain with maternal urinary metabolites: an NYU CHES study.International journal of obesity (2005) · 2022Article
- Serum metabolomic signatures of gestational diabetes in South Asian and white European women.BMJ open diabetes research & care · 2022Article
- Dynamic changes and early predictive value of branched-chain amino acids in gestational diabetes mellitus during pregnancy.Frontiers in endocrinology · 2022Article
- The mediating role of maternal metabolites between lipids and adverse pregnancy outcomes of gestational diabetes mellitus.Frontiers in medicine · 2022Article
- Review
- Urinary Metabolomic Profile of Neonates Born to Women with Gestational Diabetes Mellitus.Metabolites · 2021Article
- Longitudinal Plasma Metabolomics Profile in Pregnancy-A Study in an Ethnically Diverse U.S. Pregnancy Cohort.Nutrients · 2021Article
- Pregnancy Complications, Correlation With Placental Pathology and Neonatal Outcomes.Frontiers in clinical diabetes and healthcare · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Women with diabetes during pregnancy are at increased risk of poor maternal and neonatal outcomes. Despite this, the effects of pre-gestational (PGDM) or gestational diabetes (GDM) on metabolism during pregnancy are not well understood. In this study, we utilized metabolomics to identify serum metabolic changes in women with and without diabetes during pregnancy and the cord blood at birth. We observed elevations in tricarboxylic acid (TCA) cycle intermediates, carbohydrates, ketones, and lipids, and a decrease in amino acids across gestation in all individuals. In early gestation, PGDM had elevations in branched-chain amino acids and sugars compared to controls, whereas GDM had increased lipids and decreased amino acids during pregnancy. In both GDM and PGDM, carbohydrate and amino acid pathways were altered, but in PGDM, hemoglobin A1c and isoleucine were significantly increased compared to GDM. Cord blood from GDM and PGDM newborns had similar increases in carbohydrates and choline metabolism compared to controls, and these alterations were not maternal in origin. Our results revealed that PGDM and GDM have distinct metabolic changes during pregnancy. A better understanding of diabetic metabolism during pregnancy can assist in improved management and development of therapeutics and help mitigate poor outcomes in both the mother and newborn.
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Registered trials
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